R
Randal May
Researcher at University of Oklahoma Health Sciences Center
Publications - 71
Citations - 4408
Randal May is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Stem cell & Stem cell marker. The author has an hindex of 33, co-authored 69 publications receiving 3761 citations. Previous affiliations of Randal May include Washington University in St. Louis & United States Department of Veterans Affairs.
Papers
More filters
Journal ArticleDOI
Long-lived intestinal tuft cells serve as colon cancer–initiating cells
C. Benedikt Westphalen,Samuel Asfaha,Yoku Hayakawa,Yoshihiro Takemoto,Dana J. Lukin,Andreas H. Nuber,Anna Brandtner,Wanda Setlik,Helen Remotti,Ashlesha Muley,Xiaowei Chen,Randal May,Courtney W. Houchen,James G. Fox,Michael D. Gershon,Michael Quante,Timothy C. Wang +16 more
TL;DR: An intestinal DCLK1⁺ tuft cell population is defined that is long lived, quiescent, and important for intestinal homeostasis and regeneration, but are activated by tissue injury and can serve to initiate colon cancer.
Journal ArticleDOI
Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice.
Randal May,Terrence E. Riehl,Clayton R. Hunt,Sripathi M. Sureban,Shrikant Anant,Courtney W. Houchen +5 more
TL;DR: Targeting DCAMKL‐1 may represent a strategy for developing novel chemotherapeutic agents for treating gut stem cells with radiation‐induced stem cell apoptosis and adenomatous polyposis coli/multiple intestinal neoplasia mice to determine the effects of APC mutation.
Journal ArticleDOI
Intestinal enteroendocrine lineage cells possess homeostatic and injury-inducible stem cell activity
Kelley S. Yan,Kelley S. Yan,Olivier Gevaert,Grace X.Y. Zheng,Benedict Anchang,Chris Probert,Kathryn A. Larkin,Paige S. Davies,Zhuan fen Cheng,John S. Kaddis,Arnold Han,Arnold Han,Kelly Roelf,Ruben I. Calderon,Esther Cynn,Xiaoyi Hu,Komal Mandleywala,Julie Wilhelmy,Susan M. Grimes,David C Corney,Stéphane C. Boutet,Jessica M. Terry,Phillip Belgrader,Solongo B. Ziraldo,Tarjei S. Mikkelsen,Fengchao Wang,Richard J. von Furstenberg,Nicholas R. Smith,Parthasarathy Chandrakesan,Randal May,Mary Ann S. Chrissy,Rajan Jain,Christine A. Cartwright,Joyce C. Niland,Young-Kwon Hong,Jill L. Carrington,David T. Breault,Jonathan I. Epstein,Courtney W. Houchen,John P. Lynch,Martin G. Martin,Sylvia K. Plevritis,Christina Curtis,Hanlee P. Ji,Linheng Li,Susan J. Henning,Melissa H. Wong,Calvin J. Kuo +47 more
TL;DR: The data suggest that the EE lineage, including mature EE cells, comprises a reservoir of homeostatic and injury-inducible ISCs, extending the understanding of cellular plasticity and stemness.
Journal ArticleDOI
DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism
Sripathi M. Sureban,Randal May,Stan Lightfoot,Aimee B. Hoskins,Megan R. Lerner,Daniel J. Brackett,Russell G. Postier,Rama P. Ramanujam,Altaf Mohammed,Chinthalapally V. Rao,James H. Wyche,Shrikant Anant,Courtney W. Houchen +12 more
TL;DR: Increased expression of the putative pancreatic stem cell marker DCAMKL-1 is reported in an established KRAS transgenic mouse model of pancreatic cancer and in human pancreatic adenocarcinoma, and a functional role is demonstrated for DCAMC-1 in Pancreatic cancer.
Journal ArticleDOI
Knockdown of RNA Binding Protein Musashi-1 Leads to Tumor Regression In Vivo
Sripathi M. Sureban,Randal May,Robert J. George,Brian K. Dieckgraefe,Howard L. McLeod,Satish Ramalingam,Kumar S. Bishnupuri,Gopalan Natarajan,Shrikant Anant,Courtney W. Houchen,Courtney W. Houchen +10 more
TL;DR: The results show the involvement of Msi-1 in cancer cell proliferation, inhibition of apoptosis, and mitotic catastrophe, suggesting an important potential mechanism for its role in tumorigenesis.