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Daniel J. Fazakerley
Researcher at University of Sydney
Publications - 74
Citations - 3089
Daniel J. Fazakerley is an academic researcher from University of Sydney. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 25, co-authored 63 publications receiving 2232 citations. Previous affiliations of Daniel J. Fazakerley include University of Cambridge & National Institutes of Health.
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Journal ArticleDOI
Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2
Sean J. Humphrey,Guang Yang,Pengyi Yang,Pengyi Yang,Daniel J. Fazakerley,Jacqueline Stöckli,Jean Y. Yang,David E. James +7 more
TL;DR: The dynamic phosphoproteome described here contains numerous phosphorylation sites on proteins involved in diverse molecular functions and should serve as a useful functional resource for cell biologists.
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Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates
Nolan J. Hoffman,Benjamin L. Parker,Rima Chaudhuri,Kelsey H. Fisher-Wellman,Maximilian Kleinert,Sean J. Humphrey,Pengyi Yang,Mira Holliday,Sophie Trefely,Daniel J. Fazakerley,Jacqueline Stöckli,James G. Burchfield,Thomas E. Jensen,Raja Jothi,Bente Kiens,Jørgen F. P. Wojtaszewski,Erik A. Richter,David E. James +17 more
TL;DR: A global analysis of protein phosphorylation in human skeletal muscle biopsies from untrained healthy males before and after a single high-intensity exercise bout revealed 1,004 unique exercise-regulated phosphosites on 562 proteins, exposing the unexplored complexity of acute exercise signaling.
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Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration
Seher Balaban,Robert F. Shearer,Lisa S. Lee,Michelle van Geldermalsen,Mark Schreuder,Mark Schreuder,Harrison C. Shtein,Rose Cairns,Kristen C. Thomas,Daniel J. Fazakerley,Thomas Grewal,Jeff Holst,Darren N. Saunders,Darren N. Saunders,Andrew J. Hoy +14 more
TL;DR: It is shown that co-culture of breast cancer cells with adipocytes revealed cancer cell-stimulated depletion of adipocyte triacylglycerol, highlighting a novel and potentially important role for adipocyte lipolysis in the provision of metabolic substrates to Breast cancer cells, thereby supporting cancer progression.
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Mapping Insulin/GLUT4 Circuitry
TL;DR: The need to adopt a more global approach to expand and deepen the understanding of the molecular processes underpinning this system will enable us to identify the critical nodes that control GLUT4 traffic and decipher emergent properties of the system that are not currently apparent.
Journal ArticleDOI
Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance
Daniel J. Fazakerley,Rima Chaudhuri,Pengyi Yang,Ghassan J. Maghzal,Kristen C. Thomas,James R. Krycer,Sean J. Humphrey,Benjamin L. Parker,Kelsey H. Fisher-Wellman,Christopher C. Meoli,Nolan J. Hoffman,Ciana Diskin,James G. Burchfield,Mark J. Cowley,Warren Kaplan,Zora Modrusan,Ganesh Kolumam,Jean Yh Yang,Daniel L. T Chen,Dorit Samocha-Bonet,Jerry R. Greenfield,Kyle L. Hoehn,Roland Stocker,Roland Stocker,David E. James +24 more
TL;DR: It is suggested that mitochondrial coenzyme Q is a proximal driver of mitochondrial oxidants and insulin resistance, and that mechanisms that restore mitochondrial CoQ may be effective therapeutic targets for treating insulin resistance.