M
Mario Perro
Researcher at Hoffmann-La Roche
Publications - 43
Citations - 3860
Mario Perro is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 17, co-authored 36 publications receiving 3078 citations. Previous affiliations of Mario Perro include University College London & Harvard University.
Papers
More filters
Journal ArticleDOI
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
Erik-Oliver Glocker,Daniel Kotlarz,Kaan Boztug,E. Michael Gertz,Alejandro A. Schäffer,Fatih Noyan,Mario Perro,Jana Diestelhorst,Anna Allroth,Dhaarini Murugan,Nadine Hätscher,Dietmar Pfeifer,Karl-Walter Sykora,Martin Sauer,Hans Kreipe,Martin Lacher,Rainer Nustede,Cristina Woellner,Ulrich Baumann,Ulrich Salzer,Sibylle Koletzko,Neil Shah,Anthony W. Segal,Axel Sauerbrey,Stephan Buderus,Scott B. Snapper,Bodo Grimbacher,Christoph Klein +27 more
TL;DR: Mutations in genes encoding the IL10R subunit proteins were found in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine, and resulted in disease remission in one patient.
Journal ArticleDOI
Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation
Lorena Riol-Blanco,Jose Ordovas-Montanes,Mario Perro,Elena Naval,Aude Thiriot,David Alvarez,Silke Paust,John N. Wood,Ulrich H. von Andrian +8 more
TL;DR: Findings indicate that TRPV1+Nav1.8+ nociceptors, by interacting with DDCs, regulate the IL-23/IL-17 pathway and control cutaneous immune responses.
Journal ArticleDOI
A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells
Georg Stary,Andrew J. Olive,Aleksandar F. Radovic-Moreno,David C. Gondek,David Alvarez,Pamela Basto,Mario Perro,Vladimir Vrbanac,Andrew M. Tager,Jinjun Shi,Jeremy Yethon,Omid C. Farokhzad,Omid C. Farokhzad,Robert Langer,Michael N. Starnbach,Ulrich H. von Andrian,Ulrich H. von Andrian +16 more
TL;DR: In this article, the authors show that UV-caused chlamydia trachomatis infection induces a long-lived protection in conventional and humanized mice, using charge switching synthetic adjuvant particles (cSAPs).
Journal ArticleDOI
A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors.
Marina Bacac,Tanja Fauti,Johannes Sam,Sara Colombetti,Tina Weinzierl,Djamila Ouaret,Walter F. Bodmer,Steffi Lehmann,Hofer Thomas U,Ralf Hosse,Ekkehard Moessner,Oliver Ast,Peter Bruenker,Sandra Grau-Richards,Teilo H Schaller,Annette Seidl,Christian Gerdes,Mario Perro,Nicolini Valeria G,Nathalie Steinhoff,Sherri Dudal,Sebastian Neumann,Thomas von Hirschheydt,Christiane Jaeger,Jose Saro,Vaios Karanikas,Christian Klein,Pablo Umana +27 more
TL;DR: CEA TCB is a novel generation TCB displaying potent antitumor activity; it is efficacious in poorly infiltrated tumors where it increases T-cell infiltration and generates a highly inflamed tumor microenvironment.
Journal ArticleDOI
Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome
Cristina Woellner,E. Michael Gertz,Alejandro A. Schäffer,M. Lagos,Mario Perro,Erik-Oliver Glocker,Maria Cristina Pietrogrande,Fausto Cossu,José Luis Franco,Núria Matamoros,Barbara Pietrucha,Edyta Heropolitańska-Pliszka,Mehdi Yeganeh,Mostafa Moin,Teresa Espanol,Stephan Ehl,Andrew R. Gennery,Mario Abinun,Anna Bręborowicz,Tim Niehues,Sara Sebnem Kilic,Anne K. Junker,Stuart E. Turvey,Alessandro Plebani,Berta Sánchez,Ben Zion Garty,Claudio Pignata,Caterina Cancrini,Jiri Litzman,Ozden Sanal,Ulrich Baumann,Rosa Bacchetta,Amy P. Hsu,Joie Davis,Lennart Hammarström,E. Graham Davies,Efrem Eren,Peter D. Arkwright,Jukka S. Moilanen,Dorothee Viemann,Sujoy Khan,László Maródi,Andrew J. Cant,Alexandra F. Freeman,Jennifer M. Puck,Steven M. Holland,Bodo Grimbacher +46 more
TL;DR: Diagnostic guidelines for STAT3-deficient HIES are proposed based on a machine-learning approach to identify which features best predict a STAT3 mutation.