D
Dhaarini Murugan
Researcher at Oregon Health & Science University
Publications - 15
Citations - 2025
Dhaarini Murugan is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Inflammatory bowel disease & Medicine. The author has an hindex of 7, co-authored 9 publications receiving 1769 citations. Previous affiliations of Dhaarini Murugan include Hannover Medical School & Ludwig Maximilian University of Munich.
Papers
More filters
Journal ArticleDOI
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
Erik-Oliver Glocker,Daniel Kotlarz,Kaan Boztug,E. Michael Gertz,Alejandro A. Schäffer,Fatih Noyan,Mario Perro,Jana Diestelhorst,Anna Allroth,Dhaarini Murugan,Nadine Hätscher,Dietmar Pfeifer,Karl-Walter Sykora,Martin Sauer,Hans Kreipe,Martin Lacher,Rainer Nustede,Cristina Woellner,Ulrich Baumann,Ulrich Salzer,Sibylle Koletzko,Neil Shah,Anthony W. Segal,Axel Sauerbrey,Stephan Buderus,Scott B. Snapper,Bodo Grimbacher,Christoph Klein +27 more
TL;DR: Mutations in genes encoding the IL10R subunit proteins were found in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine, and resulted in disease remission in one patient.
Journal ArticleDOI
Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.
Daniel Kotlarz,Daniel Kotlarz,Rita Beier,Dhaarini Murugan,Dhaarini Murugan,Jana Diestelhorst,Jana Diestelhorst,Ole Jensen,Ole Jensen,Kaan Boztug,Dietmar Pfeifer,Hans Kreipe,Eva Doreen Pfister,Ulrich Baumann,Jacek Puchałka,Jens Bohne,Odul Egritas,Buket Dalgic,Kaija-Leena Kolho,Axel Sauerbrey,Stephan Buderus,Tayfun Güngör,Axel Enninger,Yu Kar Ling Koda,Graziella Guariso,Batia Weiss,Selim Corbacioglu,Piotr Socha,Nuray Uslu,Ayse Metin,Ghassan Wahbeh,Khalid Husain,Dina Ramadan,Waleed Al Herz,Bodo Grimbacher,Martin Sauer,Karl Walter Sykora,Sibylle Koletzko,Christoph Klein,Christoph Klein +39 more
TL;DR: It is indicated that infantile IBD patients with perianal disease should be screened for IL-10 and IL-11R deficiency and that allogeneic HSCT can induce remission in those with IL- 10R deficiency.
Journal ArticleDOI
A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency
Bénédicte Neven,Emilie Mamessier,Julie Bruneau,Sophie Kaltenbach,Daniel Kotlarz,Felipe Suarez,Julien Masliah-Planchon,Katy Billot,Katy Billot,Katy Billot,Danielle Canioni,Pierre Frange,Pierre Frange,Isabelle Radford-Weiss,Vahid Asnafi,Dhaarini Murugan,Christine Bole,Patrick Nitschke,Patrick Nitschke,Olivier Goulet,Jean-Laurent Casanova,Stéphane Blanche,Stéphane Blanche,Capucine Picard,Olivier Hermine,Olivier Hermine,Olivier Hermine,Frédéric Rieux-Laucat,Frédéric Rieux-Laucat,Nicole Brousse,Frederic Davi,Véronique Baud,Véronique Baud,Véronique Baud,Christoph Klein,Bertrand Nadel,Frank M. Ruemmele,Alain Fischer +37 more
TL;DR: An unexpected role of the IL-10R pathway in lymphomagenesis is revealed, associated with a high risk of developing B-cell lymphoma between the ages of 5 and 6 years.
Journal ArticleDOI
Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy
Terry R. Medler,Dhaarini Murugan,Wesley Horton,Sushil Kumar,Tiziana Cotechini,Alexandra M. Forsyth,Patrick Leyshock,Justin J. Leitenberger,Molly Kulesz-Martin,Adam A. Margolin,Zena Werb,Lisa M. Coussens +11 more
TL;DR: Therapeutic inhibition of C5aR1 via the peptide antagonist PMX-53 improved efficacy of paclitaxel chemotherapy associated with increased presence and cytotoxic properties of CXCR3+ effector memory CD8+ T cells in carcinomas, dependent on both macrophage transcriptional programming and IFNγ.
Journal ArticleDOI
Inherited biallelic CSF3R mutations in severe congenital neutropenia
Alexa Triot,Päivi M Järvinen,Juan I. Aróstegui,Dhaarini Murugan,Naschla Kohistani,Jose Luis Dapena Díaz,Tomas Racek,Jacek Puchałka,E. Michael Gertz,Alejandro A. Schäffer,Daniel Kotlarz,Dietmar Pfeifer,Christina Díaz de Heredia Rubio,Mehmet Akif Ozdemir,Turkan Patiroglu,Musa Karakukcu,José Sanchez de Toledo Codina,Jordi Yagüe,Ivo P. Touw,Ekrem Unal,Christoph Klein +20 more
TL;DR: A novel genetic SCN type in 2 unrelated families associated with recessively inherited loss-of-function mutations in CSF3R, encoding the granulocyte colony-stimulating factor (G-CSF) receptor is described.