E
Ernesto Freire
Researcher at Johns Hopkins University
Publications - 276
Citations - 22367
Ernesto Freire is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Isothermal titration calorimetry & Protein folding. The author has an hindex of 82, co-authored 274 publications receiving 21112 citations. Previous affiliations of Ernesto Freire include Johns Hopkins University School of Medicine & Harvard University.
Papers
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Journal ArticleDOI
HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
Peter D. Kwong,Peter D. Kwong,Michael L. Doyle,Michael L. Doyle,David J. Casper,Claudia Cicala,Stephanie A. Leavitt,Shahzad Majeed,Shahzad Majeed,Tavis D. Steenbeke,Miro Venturi,Irwin Chaiken,Michael Fung,Hermann Katinger,Paul W. I. H. Parren,James E. Robinson,Donald Van Ryk,Liping Wang,Dennis R. Burton,Ernesto Freire,Richard T. Wyatt,Richard T. Wyatt,Joseph Sodroski,Wayne A. Hendrickson,Wayne A. Hendrickson,James Arthos +25 more
TL;DR: It is shown that recognition by receptor-binding-site antibodies induces conformational change, and conformational masking enables HIV-1 to maintain receptor binding and simultaneously to resist neutralization.
Journal ArticleDOI
Direct measurement of protein binding energetics by isothermal titration calorimetry
TL;DR: Because isothermal titration calorimetry has the capability to measure different energetic contributions to the binding affinity, it provides a unique bridge between computational and experimental analysis and is increasingly becoming an essential tool in molecular design.
Journal ArticleDOI
Isothermal titration calorimetry
Book ChapterDOI
Thermodynamics of structural stability and cooperative folding behavior in proteins.
Kenneth P. Murphy,Ernesto Freire +1 more
TL;DR: Thermodynamic stability and cooperative interactions in proteins can be determined by hierarchical approach to partition functions, thermodynamic dissection of cooperative interactions, and classification of cooperative forces and mechanisms.
Journal ArticleDOI
Do enthalpy and entropy distinguish first in class from best in class
TL;DR: The structure/activity relationships (SARs) as mentioned in this paper explicitly incorporate the interplay between enthalpy and entropy and accelerate the optimization process are being developed and gaining popularity in the literature.