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Daniela Fraccarollo
Researcher at University of Würzburg
Publications - 63
Citations - 3834
Daniela Fraccarollo is an academic researcher from University of Würzburg. The author has contributed to research in topics: Heart failure & Myocardial infarction. The author has an hindex of 33, co-authored 59 publications receiving 3539 citations. Previous affiliations of Daniela Fraccarollo include Technische Universität München & Hannover Medical School.
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Journal ArticleDOI
Endothelial Nitric Oxide Synthase Uncoupling Impairs Endothelial Progenitor Cell Mobilization and Function in Diabetes
Thomas Thum,Daniela Fraccarollo,Maximilian Schultheiss,Sabrina Froese,Paolo Galuppo,Julian D. Widder,Dimitrios Tsikas,Georg Ertl,Johann Bauersachs +8 more
TL;DR: Uncoupling of the endothelial nitric oxide synthase (eNOS) resulting in superoxide anion (O2−) formation instead ofNitric oxide (NO) causes diabetic endothelial dysfunction and subsequent reduction of EPC levels and impairment of E PC function likely contributes to the pathogenesis of vascular disease in diabetes.
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Improvement of Left Ventricular Remodeling and Function by Hydroxymethylglutaryl Coenzyme A Reductase Inhibition With Cerivastatin in Rats With Heart Failure After Myocardial Infarction
TL;DR: Cerivastatin improved LV remodeling and function in rats with heart failure and was associated with an attenuated LV expression of fetal myosin heavy chain isoenzymes and collagen I.
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Gut Microbiota–Dependent Trimethylamine N-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes
Arash Haghikia,Xinmin S. Li,Thomas G. Liman,Nils Bledau,David Schmidt,Friederike Zimmermann,Nicolle Kränkel,Christian Widera,Kristina Sonnenschein,Aiden Haghikia,Karin Weissenborn,Daniela Fraccarollo,Markus M. Heimesaat,Johann Bauersachs,Zeneng Wang,Weifei Zhu,Udo Bavendiek,Stanley L. Hazen,Stanley L. Hazen,Matthias Endres,Ulf Landmesser +20 more
TL;DR: The data support the notion that TMAO-related increase of proinflammatory monocytes may add to elevated cardiovascular risk of patients with increased TMAOs, as well as in mice with depleted gut microbiota.
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Deletion of Cardiomyocyte Mineralocorticoid Receptor Ameliorates Adverse Remodeling After Myocardial Infarction
Daniela Fraccarollo,Daniela Fraccarollo,Stefan Berger,Paolo Galuppo,Paolo Galuppo,Susanne Kneitz,Lutz Hein,Günther Schütz,Stefan Frantz,Georg Ertl,Johann Bauersachs +10 more
TL;DR: Cardiomyocyte-specific MR deficiency improved infarct healing and prevented progressive adverse cardiac remodeling, contractile dysfunction, and molecular alterations in ischemic heart failure, highlighting the importance of cardiomyocytes MR for heart failure development and progression.
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Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction.
Daniela Fraccarollo,Paolo Galuppo,Steven K Hildemann,Michael Christ,Georg Ertl,Johann Bauersachs +5 more
TL;DR: The aldosterone blocker eplerenone improved LV remodeling in rats with LV dysfunction after extensive MI by a complementary prevention of LV fibrosis, cardiac hypertrophy, and molecular alterations.