Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction.
Daniela Fraccarollo,Paolo Galuppo,Steven K Hildemann,Michael Christ,Georg Ertl,Johann Bauersachs +5 more
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The aldosterone blocker eplerenone improved LV remodeling in rats with LV dysfunction after extensive MI by a complementary prevention of LV fibrosis, cardiac hypertrophy, and molecular alterations.About:
This article is published in Journal of the American College of Cardiology.The article was published on 2003-11-05 and is currently open access. It has received 175 citations till now. The article focuses on the topics: Eplerenone & Trandolapril.read more
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Prevention of heart failure: a scientific statement from the American Heart Association Councils on Epidemiology and Prevention, Clinical Cardiology, Cardiovascular Nursing, and High Blood Pressure Research; Quality of Care and Outcomes Research Interdisciplinary Working Group; and Functional Genomics and Translational Biology Interdisciplinary Working Group.
Douglas D. Schocken,Emelia J. Benjamin,Gregg C. Fonarow,Harlan M. Krumholz,Daniel Levy,George A. Mensah,Jagat Narula,Eileen Stuart Shor,James B. Young,Yuling Hong +9 more
TL;DR: In this article, the authors proposed to identify and treat patients with asymptomatic left ventricular systolic dysfunction (Stage B HF) and how to prevent its development.
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Structural and functional remodeling of the left atrium: clinical and therapeutic implications for atrial fibrillation.
TL;DR: The mechanisms involved in LA remodeling are described and the existing and potential therapeutic options for its reversal are highlighted, and implications for AF development are highlighted.
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Eplerenone Reduces Mortality 30 Days After Randomization Following Acute Myocardial Infarction in Patients With Left Ventricular Systolic Dysfunction and Heart Failure
Bertram Pitt,Harvey D. White,Jose C. Nicolau,Felipe Martinez,Mihai Gheorghiade,Michael Aschermann,Dirk J. van Veldhuisen,Faiez Zannad,Henry Krum,Robin Mukherjee,John Vincent +10 more
TL;DR: Eplerenone 25 mg/day significantly reduced all-cause mortality 30 days after randomization and should be administered in the hospital after AMI in addition to conventional therapy in patients with an LVEF < or =40% and signs of heart failure.
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Diagnostic, Prognostic, and Therapeutic Implications of Genetic Testing for Hypertrophic Cardiomyopathy
TL;DR: It is essential that the modern-day cardiologist understand the diagnostic, prognostic, and therapeutic implications of HCM genetic testing.
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Navigating the crossroads of coronary artery disease and heart failure.
Mihai Gheorghiade,George Sopko,Leonardo De Luca,Eric J. Velazquez,John D. Parker,Philip F. Binkley,Zygmunt Sadowski,Krzysztof S. Gołba,David L. Prior,Jean L. Rouleau,Robert O. Bonow +10 more
TL;DR: The Framingham Heart Study suggests that the most common cause of HF is no longer hypertension or valvular heart disease, as it was in previous decades, but rather CAD, and this shift may be related to improved survival of patients after acute myocardial infarction.
References
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The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.
Bertram Pitt,Faiez Zannad,Willem J. Remme,Robert J. Cody,Alain Castaigne,Alfonso Perez,Jolie Palensky,Janet Wittes +7 more
TL;DR: Blockade of aldosterone receptors by spironolactone, in addition to standard therapy, substantially reduces the risk of both morbidity and death among patients with severe heart failure.
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The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure
Bertram Pitt,Faiez Zannad,Willem J. Remme,Robert J. Cody,Alain Castaigne,Alfonso Perez,Jolie Palensky,Janet Wittes +7 more
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Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Stefanie Dimmeler,Ingrid Fleming,Beate Fisslthaler,Corinna Hermann,Rudi Busse,Andreas M. Zeiher +5 more
TL;DR: It is demonstrated that the serine/threonine protein kinase Akt/PKB mediates the activation of eNOS, leading to increased NO production, and represents a novel Ca2+-independent regulatory mechanism for activation ofeNOS.
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Cardiac remodeling—concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling
TL;DR: Left ventricular end-diastolic and end-systolic volume and ejection fraction data provide support for the beneficial effects of therapeutic agents such as angiotensin-converting enzyme (ACE) inhibitors and beta-adrenergic blocking agents on the remodeling process.
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Hormones regulating cardiovascular function in patients with severe congestive heart failure and their relation to mortality. CONSENSUS Trial Study Group.
TL;DR: There is a pronounced but variable neurohormonal activation in heart failure even in patients with similar clinical findings, and the effect of enalapril on mortality is related to hormonal activation in general and the renin-angiotensin system in particular.