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Roland Züst
Researcher at Agency for Science, Technology and Research
Publications - 23
Citations - 3289
Roland Züst is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Coronavirus & Virus. The author has an hindex of 16, co-authored 21 publications receiving 2752 citations. Previous affiliations of Roland Züst include Kantonsspital St. Gallen & Wadsworth Center.
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Journal ArticleDOI
2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members
Stephane Daffis,Kristy J. Szretter,Jill Schriewer,Jianqing Li,Soonjeon Youn,John S. Errett,Tsai-Yu Lin,Stewart W. Schneller,Roland Züst,Hongping Dong,Volker Thiel,Volker Thiel,Ganes C. Sen,Volker Fensterl,William B. Klimstra,Theodore C. Pierson,R. Mark L. Buller,Michael Gale,Pei Yong Shi,Michael S. Diamond +19 more
TL;DR: It is demonstrated that a West Nile virus mutant that lacks 2′-O MTase activity was attenuated in wild-type primary cells and mice but was pathogenic in the absence of type I interferon (IFN) signalling, and suggested an evolutionary explanation for 2-O methylation of cellular mRNA: to distinguish self from non-self RNA.
Journal ArticleDOI
Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5
Roland Züst,Roland Züst,Luisa Cervantes-Barragan,Matthias Habjan,Reinhard Maier,Benjamin W. Neuman,John Ziebuhr,John Ziebuhr,Kristy J. Szretter,Susan C. Baker,Winfried Barchet,Michael S. Diamond,Stuart G. Siddell,Burkhard Ludewig,Burkhard Ludewig,Volker Thiel,Volker Thiel +16 more
TL;DR: It is demonstrated that the induction of type I interferon by viruses deficient in 2′-O-methyltransferase was dependent on the cytoplasmic RNA sensor Mda5, which suggests that RNA modifications such as 2-methylation provide a molecular signature for the discrimination of self and non-self mRNA.
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The SARS-Coronavirus-Host Interactome: Identification of Cyclophilins as Target for Pan-Coronavirus Inhibitors
Susanne Pfefferle,Julia Schöpf,Manfred Kögl,Caroline C. Friedel,Caroline C. Friedel,Marcel A. Müller,Javier Carbajo-Lozoya,Thorsten Stellberger,Ekatarina von Dall'Armi,Petra Herzog,Stefan Kallies,Daniela Niemeyer,Vanessa Ditt,Thomas Kuri,Roland Züst,Ksenia Pumpor,Rolf Hilgenfeld,Frank Schwarz,Ralf Zimmer,Imke Steffen,Friedemann Weber,Friedemann Weber,Volker Thiel,Georg Herrler,Heinz Jürgen Thiel,Christel Schwegmann-Weßels,Stefan Pöhlmann,Jürgen Haas,Jürgen Haas,Christian Drosten,Albrecht von Brunn +30 more
TL;DR: Overexpression of NSP1 and infection with live SARS-CoV strongly increased signalling through the Calcineurin/NFAT pathway and enhanced the induction of interleukin 2, compatible with late-stage immunopathogenicity and long-term cytokine dysregulation as observed in severe SARS cases.
Journal ArticleDOI
Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.
Luisa Cervantes-Barragan,Roland Züst,Friedemann Weber,Martin Spiegel,Karl S. Lang,Shizuo Akira,Volker Thiel,Burkhard Ludewig +7 more
TL;DR: In this article, plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) were demonstrated to be essential for the control of potentially lethal coronavirus infections.
Journal ArticleDOI
Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus Vaccines
Roland Züst,Luisa Cervantes-Barragan,Luisa Cervantes-Barragan,Thomas Kuri,Gjon Blakqori,Friedemann Weber,Burkhard Ludewig,Volker Thiel +7 more
TL;DR: The rational design of an attenuated recombinant coronavirus vaccine based on a deletion in the coding sequence of the non-structural protein 1 (nsp1) provides a paradigm for the development of highly efficient coronav virus vaccines.