D
Daryld Strick
Researcher at Harvard University
Publications - 10
Citations - 2146
Daryld Strick is an academic researcher from Harvard University. The author has contributed to research in topics: Epitope & Cytotoxic T cell. The author has an hindex of 10, co-authored 10 publications receiving 2097 citations. Previous affiliations of Daryld Strick include Howard Hughes Medical Institute.
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Journal ArticleDOI
Comprehensive Epitope Analysis of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T-Cell Responses Directed against the Entire Expressed HIV-1 Genome Demonstrate Broadly Directed Responses, but No Correlation to Viral Load
Marylyn M. Addo,Xu G. Yu,Almas Rathod,Daniel E. Cohen,Robert L. Eldridge,Daryld Strick,Mary N. Johnston,Colleen Corcoran,Alysse G. Wurcel,Cecily A. Fitzpatrick,Margaret E. Feeney,William Rodriguez,Nesli Basgoz,Rika Draenert,David Stone,Christian Brander,Philip J. R. Goulder,Philip J. R. Goulder,Eric S. Rosenberg,Marcus Altfeld,Bruce D. Walker +20 more
TL;DR: The data suggest that the impact of T-cell responses on control of viral replication cannot be explained by the mere quantification of the magnitude and breadth of the CD8+-T-cell response, even if a comprehensive pan-genome screening approach is applied.
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Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection.
Marcus Altfeld,Marylyn M. Addo,Eric S. Rosenberg,Frederick Hecht,Paul K. Lee,Martin Vogel,Xu G. Yu,Rika Draenert,Mary N. Johnston,Daryld Strick,Todd M. Allen,Margaret E. Feeney,James O. Kahn,Rafick Pierre Sekaly,Jay A. Levy,Jürgen K. Rockstroh,Philip J. R. Goulder,Bruce D. Walker +17 more
TL;DR: It is demonstrated that host genetic factors can influence the clinical manifestations of acute HIV-1 infection and provide a functional link between HLA-B57 and viral immune control.
Journal ArticleDOI
Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection
Todd M. Allen,Marcus Altfeld,Xu G. Yu,Kristin M. O'Sullivan,Mathias Lichterfeld,Sylvie Le Gall,Mina John,Bianca R. Mothé,Paul K. Lee,Elizabeth T. Kalife,Daniel E. Cohen,Kenneth A. Freedberg,Daryld Strick,Mary N. Johnston,Alessandro Sette,Eric S. Rosenberg,Simon Mallal,Philip J. R. Goulder,Philip J. R. Goulder,Christian Brander,Bruce D. Walker +20 more
TL;DR: It is demonstrated that mutations within the flanking region of an HIV-1 epitope can impair recognition by an established CD8 T- cell response and that transmission of these mutations alters the acute-phase CD8+ T-cell response.
Journal ArticleDOI
Limited durability of viral control following treated acute HIV infection.
Daniel Kaufmann,Mathias Lichterfeld,Marcus Altfeld,Marylyn M. Addo,Mary N. Johnston,Paul K. Lee,Bradford S. Wagner,Elizabeth T. Kalife,Daryld Strick,Eric S. Rosenberg,Bruce D. Walker,Bruce D. Walker +11 more
TL;DR: In this article, a longitudinal follow-up of a single-arm, open-label study assessing the impact of STI in the setting of acute HIV-1 infection was presented.
Journal ArticleDOI
Consistent patterns in the development and immunodominance of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T-cell responses following acute HIV-1 infection.
Xu G. Yu,Marylyn M. Addo,Eric S. Rosenberg,William Rodriguez,Paul K. Lee,Cecily A. Fitzpatrick,Mary N. Johnston,Daryld Strick,Philip J. R. Goulder,Philip J. R. Goulder,Bruce D. Walker,Marcus Altfeld +11 more
TL;DR: It is demonstrated that HIV-1-specific CD8+ T-cell responses can ultimately target a previously unexpected and unprecedented number of epitopes in a single infected individual, even though these are not detectable during the initial exposure to virus.