S
Sylvie Le Gall
Researcher at Ragon Institute of MGH, MIT and Harvard
Publications - 50
Citations - 5405
Sylvie Le Gall is an academic researcher from Ragon Institute of MGH, MIT and Harvard. The author has contributed to research in topics: Epitope & Cytotoxic T cell. The author has an hindex of 29, co-authored 50 publications receiving 5074 citations. Previous affiliations of Sylvie Le Gall include Pasteur Institute & Howard Hughes Medical Institute.
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Journal ArticleDOI
HIV Coreceptor Downregulation as Antiviral Principle: SDF-1α–dependent Internalization of the Chemokine Receptor CXCR4 Contributes to Inhibition of HIV Replication
Ali Amara,Sylvie Le Gall,Olivier Schwartz,Jean Salamero,Monica Montes,Pius Loetscher,Marco Baggiolini,Jean-Louis Virelizier,Fernando Arenzana-Seisdedos +8 more
TL;DR: The results indicate that the ability of the coreceptor to internalize is not required for HIV entry, but contributes to the HIV suppressive effect of CXC and CC chemokines.
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Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.
Daniel Kaufmann,Daniel G. Kavanagh,Florencia Pereyra,Florencia Pereyra,John Zaunders,Elizabeth W Mackey,Toshiyuki Miura,Toshiyuki Miura,Sarah Palmer,Mark A. Brockman,Mark A. Brockman,Almas Rathod,Alicja Piechocka-Trocha,Alicja Piechocka-Trocha,Brett Baker,Baogong Zhu,Sylvie Le Gall,Michael T. Waring,Michael T. Waring,Ryan Ahern,Kristin Moss,Anthony D. Kelleher,John M. Coffin,Gordon J. Freeman,Eric S. Rosenberg,Bruce D. Walker,Bruce D. Walker +26 more
TL;DR: It is reported that the inhibitory immunoregulatory receptor CTLA-4 was selectively upregulated in human immunodeficiency virus–specific CD4+ T cells but not CD8- T cells in all categories of HIV-infected subjects evaluated, with the exception of rare people able to control viremia in the absence of antiretroviral therapy.
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Nef Interacts with the μ Subunit of Clathrin Adaptor Complexes and Reveals a Cryptic Sorting Signal in MHC I Molecules
Sylvie Le Gall,Lars Erdtmann,Serge Benichou,Clarisse Berlioz-Torrent,Langxia Liu,Richard Benarous,Jean-Michel Heard,Olivier Schwartz +7 more
TL;DR: It is shown that the Nef protein affects the intracellular sorting of HLA-A and -B molecules in HIV-infected cells, likely facilitating the connection between MHC I and the clathrin-dependent sorting machinery.
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Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication.
Arne Schneidewind,Mark A. Brockman,Mark A. Brockman,Ruifeng Yang,Rahma I. Adam,Bin Li,Sylvie Le Gall,Charles R. Rinaldo,Sharon L. Craggs,Rachel L. Allgaier,Karen A. Power,Thomas Kuntzen,Chang-Shung Tung,Montiago X. LaBute,Sandra M. Mueller,Thomas Harrer,Andrew J. McMichael,Philip J. R. Goulder,Christopher Aiken,Christian Brander,Anthony D. Kelleher,Todd M. Allen +21 more
TL;DR: It is concluded that the impact of the R264K substitution on capsid structure constrains viral escape and enables long-term maintenance of the dominant CTL response against B27-KK10, providing an explanation for the protective effect of HLA-B27 during HIV infection.
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Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.
Rika Draenert,Sylvie Le Gall,Katja Pfafferott,Alasdair Leslie,Polan Chetty,Christian Brander,Edward C. Holmes,Shih-Chung Chang,Margaret E. Feeney,Marylyn M. Addo,Lidia Ruiz,Danni Ramduth,P M Jeena,Marcus Altfeld,Stephanie Thomas,Yanhua Tang,Cori L. Verrill,Catherine Dixon,Julia G. Prado,Photini Kiepiela,Javier Martinez-Picado,Bruce D. Walker,Philip J. R. Goulder,Philip J. R. Goulder +23 more
TL;DR: It is demonstrated that allele-associated sequence variation within the flanking region of CTL epitopes can alter antigen processing and is of major relevance in the construction of vaccine sequences.