D
Dat Q. Tran
Researcher at Linköping University
Publications - 149
Citations - 8957
Dat Q. Tran is an academic researcher from Linköping University. The author has contributed to research in topics: FOXP3 & Lactobacillus reuteri. The author has an hindex of 37, co-authored 137 publications receiving 7706 citations. Previous affiliations of Dat Q. Tran include University of Southern California & University of California, Berkeley.
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Journal ArticleDOI
Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells
Angela M. Thornton,Patricia E. Korty,Dat Q. Tran,Elizabeth A. Wohlfert,Patrick E. Murray,Yasmine Belkaid,Ethan M. Shevach +6 more
TL;DR: Results demonstrate that Helios is potentially a specific marker of thymic-derived T Reg cells and raises the possibility that a significant percentage of Foxp3+ Treg cells are generated extrathymically.
Journal ArticleDOI
Induction of FOXP3 expression in naive human CD4+FOXP3− T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype
TL;DR: This paper showed that TCR stimulation alone was insufficient to induce FOXP3 expression in the absence of transforming growth factor β (TGFβ), whereas high levels of expression could be induced in the presence of TGFβ.
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A Cyclic Antimicrobial Peptide Produced in Primate Leukocytes by the Ligation of Two Truncated α-Defensins
Yi-Quan Tang,Jun Yuan,George Ösapay,Klara Osapay,Dat Q. Tran,Christopher J. Miller,Andre J. Ouellette,Michael E. Selsted +7 more
TL;DR: In this article, an 18-residue macrocyclic, tridisulfide antibiotic peptide was found in granules of neutrophils and monocytes, which is termed rhesus theta defensin-1 (RTD-1).
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Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
Hye Sun Kuehn,Weiming Ouyang,Bernice Lo,Elissa K. Deenick,Elissa K. Deenick,Julie E. Niemela,Danielle T. Avery,Jean Nicolas Schickel,Dat Q. Tran,Jennifer Stoddard,Yu Zhang,David M. Frucht,Bogdan Dumitriu,Phillip Scheinberg,Les R. Folio,Cathleen Frein,Susan Price,Christopher Koh,Theo Heller,Christine M. Seroogy,Anna Huttenlocher,V. Koneti Rao,Helen C. Su,David E. Kleiner,Luigi D. Notarangelo,Yajesh Rampertaap,Kenneth N. Olivier,Joshua J McElwee,Jason D. Hughes,Stefania Pittaluga,Joao Bosco Oliveira,Eric Meffre,Thomas A. Fleisher,Steven M. Holland,Michael J. Lenardo,Stuart G. Tangye,Stuart G. Tangye,Gulbu Uzel +37 more
TL;DR: The findings support the idea that CTLA4 tells the immune system when enough is enough, and Inherited human CTLA 4 haploinsufficiency demonstrates a critical quantitative role for CTLA-4 in governing T and B lymphocyte homeostasis.
Journal ArticleDOI
GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3+ regulatory T cells
TL;DR: It is demonstrated that platelets and activated Tregs co-express latent TGF-β and GARP on their membranes and that GARP or LRRC32, a leucine-rich repeat molecule of unknown function, is critical for tethering T GF-β to the cell surface.