L
Les R. Folio
Researcher at National Institutes of Health
Publications - 158
Citations - 5312
Les R. Folio is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 24, co-authored 148 publications receiving 3723 citations. Previous affiliations of Les R. Folio include Uniformed Services University of the Health Sciences.
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Journal ArticleDOI
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
Hye Sun Kuehn,Weiming Ouyang,Bernice Lo,Elissa K. Deenick,Elissa K. Deenick,Julie E. Niemela,Danielle T. Avery,Jean Nicolas Schickel,Dat Q. Tran,Jennifer Stoddard,Yu Zhang,David M. Frucht,Bogdan Dumitriu,Phillip Scheinberg,Les R. Folio,Cathleen Frein,Susan Price,Christopher Koh,Theo Heller,Christine M. Seroogy,Anna Huttenlocher,V. Koneti Rao,Helen C. Su,David E. Kleiner,Luigi D. Notarangelo,Yajesh Rampertaap,Kenneth N. Olivier,Joshua J McElwee,Jason D. Hughes,Stefania Pittaluga,Joao Bosco Oliveira,Eric Meffre,Thomas A. Fleisher,Steven M. Holland,Michael J. Lenardo,Stuart G. Tangye,Stuart G. Tangye,Gulbu Uzel +37 more
TL;DR: The findings support the idea that CTLA4 tells the immune system when enough is enough, and Inherited human CTLA 4 haploinsufficiency demonstrates a critical quantitative role for CTLA-4 in governing T and B lymphocyte homeostasis.
Journal ArticleDOI
Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency
Carrie L. Lucas,Hye Sun Kuehn,Fang Zhao,Julie E. Niemela,Elissa K. Deenick,Umaimainthan Palendira,Danielle T. Avery,Leen Moens,Jennifer L. Cannons,Matthew Biancalana,Jennifer Stoddard,Weiming Ouyang,David M. Frucht,V. Koneti Rao,T. Prescott Atkinson,Anahita Agharahimi,Ashleigh A. Hussey,Les R. Folio,Kenneth N. Olivier,Thomas A. Fleisher,Stefania Pittaluga,Steven M. Holland,Jeffrey I. Cohen,Joao Bosco Oliveira,Stuart G. Tangye,Pamela L. Schwartzberg,Michael J. Lenardo,Gulbu Uzel +27 more
TL;DR: T cells from patients with heterozygous for three different germline, gain-of-function mutations in PIK3CD exhibited increased phosphorylation of the kinase Akt and hyperactivation of the metabolic checkpoint kinase mTOR, enhanced glucose uptake and terminal effector differentiation in vitro.
Journal ArticleDOI
Preparing Medical Imaging Data for Machine Learning.
Martin J. Willemink,Wojciech A. Koszek,Cailin Hardell,Jie Wu,Dominik Fleischmann,Hugh Harvey,Les R. Folio,Ronald M. Summers,Daniel L. Rubin,Matthew P. Lungren +9 more
TL;DR: Fundamental steps for preparing medical imaging data in AI algorithm development are described, current limitations to data curation are explained, and new approaches to address the problem of data availability are explored.
Journal ArticleDOI
Automatic Tuberculosis Screening Using Chest Radiographs
Stefan Jaeger,Alexandros Karargyris,Sema Candemir,Les R. Folio,Jenifer Siegelman,Fiona M. Callaghan,Zhiyun Xue,Kannappan Palaniappan,R. Singh,Sameer Antani,George R. Thoma,Yi-Xiang J. Wang,Pu-Xuan Lu,Clement J. McDonald +13 more
TL;DR: The proposed computer-aided diagnostic system for TB screening, which is ready for field deployment, achieves a performance that approaches the performance of human experts.
Journal ArticleDOI
JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies
Gina A. Montealegre Sanchez,Adam L Reinhardt,Suzanne E. Ramsey,Helmut Wittkowski,Philip J. Hashkes,Yackov Berkun,Susanne Schalm,Sara Murias,Jason Dare,Diane Brown,Deborah L. Stone,Ling Gao,Thomas Klausmeier,Dirk Foell,Adriana Almeida de Jesus,Dawn Chapelle,Hanna Kim,Samantha Dill,Robert A. Colbert,Laura Failla,B. Kost,Michelle O'Brien,James C. Reynolds,Les R. Folio,Katherine R. Calvo,Scott M. Paul,Nargues Weir,Alessandra Brofferio,Ariane Soldatos,Angelique Biancotto,Edward W. Cowen,John J. Digiovanna,Massimo Gadina,Andrew Lipton,Colleen Hadigan,Steven M. Holland,Joseph A. Fontana,Ahmad Samer Alawad,Rebecca J. Brown,Kristina I. Rother,Theo Heller,Kristina M Brooks,Parag Kumar,Stephen R. Brooks,Meryl Waldman,Harsharan K. Singh,Volker Nickeleit,Maria Silk,Apurva Prakash,Jonathan Janes,Seza Ozen,Paul G. Wakim,Paul A. Brogan,William L. Macias,Raphaela Goldbach-Mansky +54 more
TL;DR: Upon baricitinib treatment, clinical manifestations and inflammatory and IFN biomarkers improved in patients with the monogenic interferonopathies CANDLE, SAVI, and other interfer onopathies.