E
Elissa K. Deenick
Researcher at Garvan Institute of Medical Research
Publications - 83
Citations - 7888
Elissa K. Deenick is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Immune system & Cytotoxic T cell. The author has an hindex of 40, co-authored 69 publications receiving 6815 citations. Previous affiliations of Elissa K. Deenick include University of Sydney & Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
Hye Sun Kuehn,Weiming Ouyang,Bernice Lo,Elissa K. Deenick,Elissa K. Deenick,Julie E. Niemela,Danielle T. Avery,Jean Nicolas Schickel,Dat Q. Tran,Jennifer Stoddard,Yu Zhang,David M. Frucht,Bogdan Dumitriu,Phillip Scheinberg,Les R. Folio,Cathleen Frein,Susan Price,Christopher Koh,Theo Heller,Christine M. Seroogy,Anna Huttenlocher,V. Koneti Rao,Helen C. Su,David E. Kleiner,Luigi D. Notarangelo,Yajesh Rampertaap,Kenneth N. Olivier,Joshua J McElwee,Jason D. Hughes,Stefania Pittaluga,Joao Bosco Oliveira,Eric Meffre,Thomas A. Fleisher,Steven M. Holland,Michael J. Lenardo,Stuart G. Tangye,Stuart G. Tangye,Gulbu Uzel +37 more
TL;DR: The findings support the idea that CTLA4 tells the immune system when enough is enough, and Inherited human CTLA 4 haploinsufficiency demonstrates a critical quantitative role for CTLA-4 in governing T and B lymphocyte homeostasis.
Journal ArticleDOI
Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency
Carrie L. Lucas,Hye Sun Kuehn,Fang Zhao,Julie E. Niemela,Elissa K. Deenick,Umaimainthan Palendira,Danielle T. Avery,Leen Moens,Jennifer L. Cannons,Matthew Biancalana,Jennifer Stoddard,Weiming Ouyang,David M. Frucht,V. Koneti Rao,T. Prescott Atkinson,Anahita Agharahimi,Ashleigh A. Hussey,Les R. Folio,Kenneth N. Olivier,Thomas A. Fleisher,Stefania Pittaluga,Steven M. Holland,Jeffrey I. Cohen,Joao Bosco Oliveira,Stuart G. Tangye,Pamela L. Schwartzberg,Michael J. Lenardo,Gulbu Uzel +27 more
TL;DR: T cells from patients with heterozygous for three different germline, gain-of-function mutations in PIK3CD exhibited increased phosphorylation of the kinase Akt and hyperactivation of the metabolic checkpoint kinase mTOR, enhanced glucose uptake and terminal effector differentiation in vitro.
Journal ArticleDOI
The origins, function, and regulation of T follicular helper cells.
Cindy S. Ma,Elissa K. Deenick,Elissa K. Deenick,Marcel Batten,Marcel Batten,Stuart G. Tangye,Stuart G. Tangye +6 more
TL;DR: Unraveling the cellular and molecular requirements underlying Tfh cell formation and maintenance will help to identify molecules that could be targeted for the treatment of immunological diseases that are characterized by insufficient or excessive Ab responses.
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The good, the bad and the ugly - TFH cells in human health and disease.
Stuart G. Tangye,Cindy S. Ma,Cindy S. Ma,Robert Brink,Robert Brink,Elissa K. Deenick,Elissa K. Deenick +6 more
TL;DR: The elucidation of the mechanisms that regulate TFH cell differentiation, function and fate should highlight targets for novel therapeutics.
Journal ArticleDOI
B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans
Danielle T. Avery,Elissa K. Deenick,Elissa K. Deenick,Cindy S. Ma,Cindy S. Ma,Santi Suryani,Santi Suryani,Nicholas Simpson,Gary Y. Chew,Tyani D. Chan,Tyani D. Chan,Umamainthan Palendira,Umamainthan Palendira,Jacinta Bustamante,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Sharon Choo,Karl Bleasel,Jane Peake,Cecile King,Cecile King,Martyn A. French,Dan Engelhard,Sami Al-Hajjar,Saleh Al-Muhsen,Klaus Magdorf,Joachim Roesler,Peter D. Arkwright,Pravin Hissaria,D. Sean Riminton,Melanie Wong,Robert Brink,Robert Brink,Robert Brink,David A. Fulcher,Jean-Laurent Casanova,Jean-Laurent Casanova,Matthew C. Cook,Stuart G. Tangye,Stuart G. Tangye +39 more
TL;DR: STAT3-activating cytokines such as IL-21 underpin Ag-specific humoral immune responses and provide a mechanism for the functional antibody deficit in STAT3-deficient patients.