D
David A. Kass
Researcher at Johns Hopkins University School of Medicine
Publications - 605
Citations - 63963
David A. Kass is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Heart failure & Cardiac resynchronization therapy. The author has an hindex of 127, co-authored 580 publications receiving 58747 citations. Previous affiliations of David A. Kass include University of Pittsburgh & Johns Hopkins University.
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Journal ArticleDOI
Oxygen radical-mediated reduction in basal and agonist-evoked NO release in isolated rat heart.
Nazareno Paolocci,Roberto Biondi,Marco Bettini,Chang Il Lee,Carlos O. Berlowitz,Ruggero Rossi,Yong Xia,Giuseppe Ambrosio,Antonio L'Abbate,David A. Kass,Jay L. Zweier +10 more
TL;DR: OfR severely impair NO-mediated coronary vasorelaxation affecting both basal and agonist-evoked NO release but not eNOS activity, however, EL also significantly blunts NOS/COX-independent vasodilation suggesting alteration of other vasodilatative pathways.
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Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor.
An L. Moens,Jordan S Leyton-Mange,Xiaolin Niu,Xiaolin Niu,Ronghua Yang,Oscar H. Cingolani,Elisabeth K. Arkenbout,Hunter C. Champion,Djahida Bedja,Kathleen L. Gabrielson,Juan Chen,Yong Xia,Ashley B. Hale,Keith M. Channon,Marc K. Halushka,Norman Barker,Floris L. Wuyts,Pawel M. Kaminski,Michael S. Wolin,Michael S. Wolin,David A. Kass,Lili A. Barouch +21 more
TL;DR: A cardioprotective role for the beta3-AR is suggested in modulating oxidative stress and adverse remodeling in the failing heart, all of which can be rescued with exogenous BH4.
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In vitro system to study realistic pulsatile flow and stretch signaling in cultured vascular cells
Xinqi Peng,Fabio A. Recchia,Barry J. Byrne,Ilan S. Wittstein,Roy C. Ziegelstein,David A. Kass +5 more
TL;DR: A novel real-time servo-controlled perfusion system that exposes endothelial cells grown in nondistensible or distensible tubes to realistic pulse pressures and phasic shears at physiological mean pressures provides the first in vitro application of realistic mechanical pulsatile forces on vascular cells.
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PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress
Mark J. Ranek,Kristen M. Kokkonen-Simon,Anna Chen,Brittany Dunkerly-Eyring,Miguel Pinilla Vera,Christian U. Oeing,Chirag H. Patel,Taishi Nakamura,Guangshuo Zhu,Djahida Bedja,Masayuki Sasaki,Ronald J. Holewinski,Jennifer E. Van Eyk,Jonathan D. Powell,Dong Ik Lee,David A. Kass +15 more
TL;DR: It is shown that phosphorylation or gain- or loss-of-function mutations at either of two adjacent serine residues in TSC2 can bidirectionally control mTORC1 activity stimulated by growth factors or haemodynamic stress, and consequently modulate cell growth and autophagy.
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Inhibition of Glycosphingolipid Synthesis Ameliorates Atherosclerosis and Arterial Stiffness in Apolipoprotein E−/− Mice and Rabbits Fed a High-Fat and -Cholesterol Diet
Subroto Chatterjee,Djahida Bedja,Sumita Mishra,Christine Amuzie,Alberto Avolio,David A. Kass,Dan E. Berkowitz,Mark Renehan +7 more
TL;DR: Inhibition of glycosphingolipid synthesis may be a novel approach to ameliorate atherosclerosis and arterial stiffness in apolipoprotein E−/− mice and rabbits.