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David A. Kass
Researcher at Johns Hopkins University School of Medicine
Publications - 605
Citations - 63963
David A. Kass is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Heart failure & Cardiac resynchronization therapy. The author has an hindex of 127, co-authored 580 publications receiving 58747 citations. Previous affiliations of David A. Kass include University of Pittsburgh & Johns Hopkins University.
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Inhibition of TRPC6 reduces systemic inflammation, cardiac fibrosis, and dramatically improves survival in dystrophic cardiomyopathy
Brian Lin,Joseph Shin,Will Jeffreys,Clarisse Lukban,Olivia A. Hanselman,Seoyoung Kwon,Nadan Wang,Steven Pullen,Antonio Filareto,David A. Kass +9 more
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Circulation Research Editors’ Yearly Report: 2002
Eduardo Marbán,Roberto Bolli,Gerda E. Breitwieser,Rudi Busse,Hal Dietz,Masao Endoh,Toren Finkel,David A. Kass,Charles J. Lowenstein,Marlene Rabinovitch,Gordon F. Tomaselli,Kara Hansell Keehan +11 more
TL;DR: Having pioneered online manuscript submission and peer review tracking among the American Heart Association journals, Circulation Research continued to see the fruits of its efforts in the time to first decision for original research articles.
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HFpEF animal models display differences in myofibril mechanics.
TL;DR: In this paper , the authors performed mechanics analysis on cardiac myofibrils from three common heart failure with preserved ejection fraction (HFpEF) animal models to assess potential differences in myoftibrillar force and relaxation kinetics, independent of higher order deficits associated with the disease.
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Unsupervised Machine Learning to Identify and Target Myofilament Mechanisms of Clinical RV Dysfunction in HFrEF
TL;DR: In this article , the authors performed unsupervised ML on right ventricular (RV) catheterization data to identify specific myofilament abnormalities indicative of RV dysfunction, and then characterized the properties of an ideal sarcomere enhancing drug to restore RV contractility.
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Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension
Vivek Jani,M. Imran Aslam,Axel J. Fenwick,Weikang Ma,Henry Gong,Gregory N. Milburn,Devin Nissen,Ilton M. Cubero Salazar,Olivia A. Hanselman,Monica Mukherjee,Marc K. Halushka,Kenneth B. Margulies,Kenneth S. Campbell,Thomas C. Irving,David A. Kass,Steven Hsu +15 more
TL;DR: In this article , an unsupervised machine learning approach was used to characterize right ventricular (RV) myocyte contractile depression in patients with heart failure with reduced ejection fraction and pulmonary hypertension (HFrEF-PH), identifying those components reflected by clinical RV indices and uncover underlying biophysical mechanisms.