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David A. Kass
Researcher at Johns Hopkins University School of Medicine
Publications - 605
Citations - 63963
David A. Kass is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Heart failure & Cardiac resynchronization therapy. The author has an hindex of 127, co-authored 580 publications receiving 58747 citations. Previous affiliations of David A. Kass include University of Pittsburgh & Johns Hopkins University.
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Journal ArticleDOI
Circulating MicroRNA-30d is Associated with Response to Cardiac Resynchronization Therapy in Heart Failure and Regulates Cardiomyocyte Apoptosis: A Translational Pilot Study
Yonathan F. Melman,Ravi V. Shah,Ravi V. Shah,Kirsty Danielson,Junjie Xiao,Bridget Simonson,Andreas S. Barth,Khalid Chakir,Gregory D. Lewis,Zachary R Lavender,Quynh A. Truong,André G. Kléber,Ranendra K. Das,Anthony Rosenzweig,Yaoyu E. Wang,David A. Kass,Jagmeet P. Singh,Saumya Das +17 more
TL;DR: MiR-30d increase in cardiomyocytes correlates with areas of increased wall stress in HFDYS and is protective against deleterious tumor necrosis factor signaling and is associated with response to CRT in H FDYS in this translational pilot study.
Journal ArticleDOI
Cardiac fibroblasts mediate IL-17A–driven inflammatory dilated cardiomyopathy
Lei Wu,SuFey Ong,Monica V. Talor,Jobert G. Barin,G. Christian Baldeviano,David A. Kass,Djahida Bedja,Hao Zhang,Asfandyar Sheikh,Joseph B. Margolick,Yoichiro Iwakura,Noel R. Rose,Daniela Cihakova +12 more
TL;DR: IL-17A stimulates cardiac fibroblasts to produce inflammatory mediators critical for the recruitment and differentiation of myeloid cells during inflammatory dilated cardiomyopathy.
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High-Dose Folic Acid Pretreatment Blunts Cardiac Dysfunction During Ischemia Coupled to Maintenance of High-Energy Phosphates and Reduces Postreperfusion Injury
An L. Moens,Hunter C. Champion,Marc J. Claeys,Barbara Tavazzi,Pawel M. Kaminski,Michael S. Wolin,Dirk J. Borgonjon,Luc Van Nassauw,Azeb Haile,Muz Zviman,Djahida Bedja,Floris L. Wuyts,Rebecca S. Elsaesser,Paul Cos,Kathy Gabrielson,Giuseppe Lazzarino,Nazareno Paolocci,Jean-Pierre Timmermans,Christiaan J. Vrints,David A. Kass +19 more
TL;DR: FA pretreatment blunts myocardial dysfunction during ischemia and ameliorates postreperfusion injury and is coupled to preservation of high-energy phosphates, reducing subsequent reactive oxygen species generation, eNOS-uncoupling, and postreverfusion cell death.
Journal ArticleDOI
Subcellular Structures and Function of Myocytes Impaired During Heart Failure Are Restored by Cardiac Resynchronization Therapy
Frank B. Sachse,Natalia S. Torres,Eleonora Savio-Galimberti,Takeshi Aiba,David A. Kass,Gordon F. Tomaselli,John H.B. Bridge +6 more
TL;DR: The finding suggests that t-system status can provide an early marker of the success of this therapy, and could also guide us to an understanding of the loss and remodeling of proteins associated with the t- system.
Journal ArticleDOI
Mechanisms of Diastolic Dysfunction in Heart Failure
Barry A. Borlaug,David A. Kass +1 more
TL;DR: This review focuses on the mechanisms determining normal and pathologic cardiac relaxation and distensibility and highlights how these abnormalities may be therapeutically targeted to improve diastolic function in human HF.