D
David B. Danner
Researcher at National Institutes of Health
Publications - 22
Citations - 1712
David B. Danner is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Gene expression. The author has an hindex of 15, co-authored 22 publications receiving 1688 citations. Previous affiliations of David B. Danner include Harvard University.
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Journal ArticleDOI
Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu.
Michel C. Nussenzweig,Albert C. Shaw,Eric Sinn,David B. Danner,Kevin L. Holmes,Herbert C. Morse,Philip Leder +6 more
TL;DR: To determine whether it is specifically the membrane-bound form of the immunoglobulin M (IgM) heavy chain (mu) that mediates this regulation, transgenic mice were created that carry a human mu chain gene altered so that it can only direct the synthesis of the membranes-bound protein.
Journal ArticleDOI
Abundant alkali-sensitive sites in DNA of human and mouse sperm☆
Narendra P. Singh,David B. Danner,Raymond R. Tice,Michael T. McCoy,Gary D. Collins,Edward L. Schneider +5 more
TL;DR: The high frequency of single-strand DNA breaks in sperm from healthy mouse and human donors suggests that they represent a functional characteristic of condensed chromatin rather than DNA damage.
Journal ArticleDOI
DNA damage and rpair with age in individual human lymphocytes
TL;DR: Data indicate an age-related decline in DNA repair competence among a small subpopulation of lymphocytes in lymphocytes exposed in vitro to 200 rads of X-irradiation.
Journal ArticleDOI
Isolation of a cDNA that hybrid selects antiproliferative mRNA from rat liver.
J.Keith McClung,David B. Danner,David A. Stewart,James R. Smith,Edward L. Schneider,Charles K. Lumpkin,R T Dell'Orco,Mark J. Nuell +7 more
TL;DR: A partial cDNA clone isolated on the basis of its preferential hybridization to RNA from normal versus regenerating rat liver is described, resulting in a 53% decrease in the fraction of nuclei incorporating tritiated thymidine in human diploid fibroblasts.
Journal Article
The Human Prohibitin Gene Located on Chromosome 17q21 Is Mutated in Sporadic Breast Cancer
Takaaki Sato,Hiroko Saito,Jeff Swensen,Arnold Olifant,Carla N. Wood,David B. Danner,Takashi Sakamoto,Ken-ichi Takita,Fujio Kasumi,Yoshio Miki,Mark H. Skolnick,Yusuke Nakamura +11 more
TL;DR: DNA sequence analysis of 2 exons in this gene in 23 sporadic breast cancers, which showed loss of heterozygosity on the long arm of chromosome 17 or developed in patients 35 years old or younger, identified 4 cases of somatic mutation.