David Bloxham

TL;DR: Somatic mutations in the endoplasmic reticulum chaperone CALR were found in a majority of patients with myeloproliferative neoplasms with nonmutated JAK2, a finding consistent with its role as an initiating mutation in some patients.

TL;DR: This represents the first report in which a chromosome abnormality associated with MDS has been immortalized in an EBV-transformed lymphoblastoid cell line and shows that patients with apparent myeloid restriction of a chromosome deletion may in fact have a disease arising in a multipotent cell with both myeloids and lymphoid potential.

TL;DR: This research aims to provide real-time information about what is happening in the operating theatre to improve the quality of care and reduce the likelihood of adverse events.

TL;DR: In one patient, analysis of metaphase spreads showed that the 3’region of the ABL gene was deleted from one chromosome 9 and inserted into chromosome 22, and in a second patient 5’BCR sequences were missing from one copy of chromosome22, and co‐localized with 3'ABL sequences on chromosome 9.

TL;DR: Peripheral blood progenitor cells (PBPC) are increasingly used for autologous reconstitution following high‐dose chemotherapy in multiple myeloma but it is unclear whether these cells are less likely to be contaminated with malignant cells than bone marrow.