L
L. Mudie
Researcher at Wellcome Trust Sanger Institute
Publications - 3
Citations - 3226
L. Mudie is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Cancer & Mutation. The author has an hindex of 3, co-authored 3 publications receiving 2919 citations. Previous affiliations of L. Mudie include Wellcome Trust.
Papers
More filters
Journal ArticleDOI
The landscape of cancer genes and mutational processes in breast cancer
Philip J. Stephens,Patrick S. Tarpey,Helen Davies,Peter Van Loo,Peter Van Loo,Christopher Greenman,Christopher Greenman,David C. Wedge,Serena Nik-Zainal,Sancha Martin,Ignacio Varela,Graham R. Bignell,Lucy R. Yates,Lucy R. Yates,Elli Papaemmanuil,David Beare,Adam Butler,Angela Cheverton,John Gamble,Jonathan Hinton,Mingming Jia,Alagu Jayakumar,David Jones,Calli Latimer,King Wai Lau,Stuart McLaren,David J. McBride,Andrew Menzies,L. Mudie,Keiran Raine,Roland Rad,Michael Spencer Chapman,Jon W. Teague,Douglas F. Easton,Anita Langerød,Ming Ta Michael Lee,Chen-Yang Shen,Benita Tan Kiat Tee,Bernice Wong Huimin,Annegien Broeks,Ana Cristina Vargas,Gulisa Turashvili,John W.M. Martens,Aquila Fatima,Penelope Miron,Suet-Feung Chin,Gilles Thomas,Sandrine Boyault,Odette Mariani,Sunil R. Lakhani,Sunil R. Lakhani,Marc J. van de Vijver,Laura van 't Veer,John A. Foekens,Christine Desmedt,Christos Sotiriou,Andrew Tutt,Carlos Caldas,Carlos Caldas,Jorge S. Reis-Filho,Samuel Aparicio,Anne Vincent Salomon,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Andrea L. Richardson,Peter J. Campbell,Peter J. Campbell,Peter J. Campbell,P. Andrew Futreal,Michael R. Stratton +69 more
TL;DR: Strong correlations between mutation number, age at which cancer was diagnosed and cancer histological grade are found, and multiple mutational signatures are observed, including one present in about ten per cent of tumours characterized by numerous mutations of cytosine at TpC dinucleotides.
Journal ArticleDOI
Somatic CALR Mutations in Myeloproliferative Neoplasms with Nonmutated JAK2
Jyoti Nangalia,Charles E. Massie,E J Baxter,Francesca L. Nice,Gunes Gundem,David C. Wedge,Edward Avezov,Juan Li,Karoline Kollmann,David G. Kent,Athar Aziz,Anna L. Godfrey,Jonathon Hinton,Inigo Martincorena,P Van Loo,Amy V. Jones,Paola Guglielmelli,P. S. Tarpey,Heather P. Harding,J.D. Fitzpatrick,C.T. Goudie,Christina A. Ortmann,Stephen J. Loughran,Keiran Raine,David R. Jones,Adam Butler,Jon W. Teague,Sarah O’Meara,Stuart McLaren,M. Bianchi,Yvonne Silber,D. Dimitropoulou,David Bloxham,L. Mudie,Mark Maddison,Bruce W. S. Robinson,Clodagh Keohane,Cathy MacLean,Kate Hill,Kim Orchard,Sudhir Tauro,Ming-Qing Du,Mel Greaves,David G. Bowen,Brian J. P. Huntly,Claire N. Harrison,Nicholas C.P. Cross,David Ron,Alessandro M. Vannucchi,Elli Papaemmanuil,Peter J. Campbell,Anthony R. Green +51 more
TL;DR: Somatic mutations in the endoplasmic reticulum chaperone CALR were found in a majority of patients with myeloproliferative neoplasms with nonmutated JAK2, a finding consistent with its role as an initiating mutation in some patients.
Journal ArticleDOI
Processed pseudogenes acquired somatically during cancer development
Susanna L. Cooke,Adam Shlien,John Marshall,Christodoulos P. Pipinikas,Inigo Martincorena,Jose M. C. Tubio,Yang Li,Andrew Menzies,L. Mudie,Manasa Ramakrishna,Lucy R. Yates,Helen Davies,Niccolo Bolli,Graham R. Bignell,Patrick S. Tarpey,Sam Behjati,Serena Nik-Zainal,Elli Papaemmanuil,Vitor H. Teixeira,Keiran Raine,Sarah O’Meara,Maryam S Dodoran,Jon W. Teague,Adam Butler,Christine C. Iacobuzio-Donahue,Thomas Santarius,Richard Grundy,David Malkin,Mel Greaves,Nikhil C. Munshi,Adrienne M. Flanagan,David D.L. Bowtell,Sancha Martin,Denis Larsimont,Jorge S. Reis-Filho,Alex Boussioutas,Jack A. Taylor,Neil Hayes,Sam M. Janes,P. Andrew Futreal,Michael R. Stratton,Ultan McDermott,Peter J. Campbell +42 more
TL;DR: Genomic features mirror those of germline LINE element retrotranspositions, with frequent target-site duplications, consensus TTTTAA sites at insertion points, inverted rearrangements and polyA tails, and transcriptional consequences include expression of pseudogenes from UTRs or introns of target genes.