D
David F. Richards
Researcher at King's College London
Publications - 50
Citations - 4619
David F. Richards is an academic researcher from King's College London. The author has contributed to research in topics: Cytokine & Interleukin 10. The author has an hindex of 28, co-authored 50 publications receiving 4386 citations. Previous affiliations of David F. Richards include Guy's Hospital & University of Cambridge.
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Journal ArticleDOI
In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.
Franck J. Barrat,Daniel J. Cua,Andre Boonstra,David F. Richards,Chad Crain,Huub F. J. Savelkoul,René de Waal-Malefyt,Robert L. Coffman,Catherine M. Hawrylowicz,Anne O'Garra +9 more
TL;DR: It is shown that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4+ T cells to differentiate in vitro into regulatory T cells, which produced only interleukin (IL)-10, but no IL-5 and interferon (IFN)-γ, and furthermore retained strong proliferative capacity.
Journal ArticleDOI
Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients.
Emmanuel Xystrakis,Siddharth Kusumakar,Sandra Boswell,Emma Peek,Zoe Urry,David F. Richards,Tonye Adikibi,Carol Pridgeon,Margaret J. Dallman,Tuck-Kay Loke,Douglas S. Robinson,Franck J. Barrat,Anne O'Garra,Paul Lavender,Tak H. Lee,Christopher Corrigan,Catherine M. Hawrylowicz +16 more
TL;DR: It is shown here that administration of vitamin D3 to healthy individuals and SR asthmatic patients enhanced subsequent responsiveness to dexamethasone for induction of IL-10, suggesting that vitamin D 3 could potentially increase the therapeutic response to glucocorticoids in SR patients.
Journal ArticleDOI
Relationship between Serum Vitamin D, Disease Severity, and Airway Remodeling in Children with Asthma
Atul Gupta,Alies Sjoukes,David F. Richards,Winston Banya,Catherine M. Hawrylowicz,Andrew Bush,Sejal Saglani +6 more
TL;DR: Lower vitamin D levels in children with STRA were associated with increased ASM mass and worse asthma control and lung function, and the link between vitamin D, airway structure, and function suggests vitamin D supplementation may be useful in pediatric STRA.
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Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans
K Ruckemann,Lynette D. Fairbanks,E A Carrey,Catherine M. Hawrylowicz,David F. Richards,B Kirschbaum,H. A. Simmonds +6 more
TL;DR: It is proved conclusively that the prime target in proliferating human T-lymphocytes is pyrimidine biosynthesis at the level of dihydroorotic-acid dehydrogenase, and de novo purine synthesis occurred secondary to inhibition of proliferation since this was reversed by uridine rescue, except at 100 μm Leflunomide.
Journal ArticleDOI
Ligation of TLR9 induced on human IL-10–secreting Tregs by 1α,25-dihydroxyvitamin D3 abrogates regulatory function
Zoe Urry,Emmanuel Xystrakis,David F. Richards,Joanne McDonald,Zahid Sattar,David J. Cousins,Christopher Corrigan,Emma Hickman,Zarin Brown,Catherine M. Hawrylowicz +9 more
TL;DR: It is shown that TLR9 is highly expressed by human Treg secreting the antiinflammatory cytokine IL-10 induced following stimulation of blood and tissue CD3+ T cells in the presence of 1alpha,25-dihydroxyvitamin D3 (1alpha25VitD3), the active form of Vitamin D, with or without the glucocorticoid dexamethasone.