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David H. Brann
Researcher at Harvard University
Publications - 21
Citations - 2188
David H. Brann is an academic researcher from Harvard University. The author has contributed to research in topics: Olfaction & Medicine. The author has an hindex of 11, co-authored 15 publications receiving 1196 citations. Previous affiliations of David H. Brann include Columbia University Medical Center & Columbia University.
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Journal ArticleDOI
Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia.
David H. Brann,Tatsuya Tsukahara,Caleb Weinreb,Marcela Lipovsek,Koen Van den Berge,Koen Van den Berge,Boying Gong,Rebecca K. Chance,Iain C. Macaulay,Hsin-jung Chou,Russell B. Fletcher,Diya Das,Diya Das,Kelly Street,Hector Roux de Bézieux,Yoon Gi Choi,Davide Risso,Sandrine Dudoit,Elizabeth Purdom,Jonathan Mill,Ralph Abi Hachem,Hiroaki Matsunami,Darren W. Logan,Bradley J. Goldstein,Matthew S. Grubb,John Ngai,Sandeep Robert Datta +26 more
TL;DR: It is suggested that CoV-2 infection of non-neuronal cell types leads to anosmia and related disturbances in odor perception in COVID-19 patients.
Posted ContentDOI
Non-neural expression of SARS-CoV-2 entry genes in the olfactory epithelium suggests mechanisms underlying anosmia in COVID-19 patients
TL;DR: This article analyzed bulk and single cell RNA-Seq datasets to identify cell types in the olfactory epithelium that express molecules that mediate infection by SARS-CoV-2 (CoV2), the causal agent in COVID-19.
Journal ArticleDOI
COVID-19 and the Chemical Senses: Supporting Players Take Center Stage.
Keiland W. Cooper,David H. Brann,Michael C. Farruggia,Surabhi Bhutani,Robert Pellegrino,Robert Pellegrino,Tatsuya Tsukahara,Caleb Weinreb,Paule V. Joseph,Eric D. Larson,Valentina Parma,Mark W. Albers,Linda A. Barlow,Sandeep Robert Datta,Antonella Di Pizio +14 more
TL;DR: Recently developed hypotheses about how SARS-CoV-2 might alter the cells and circuits involved in chemosensory processing and thereby change perception are reviewed and future experiments are proposed to elucidate disease mechanisms.
Posted ContentDOI
Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia
David H. Brann,Tatsuya Tsukahara,Caleb Weinreb,Marcela Lipovsek,Koen Van den Berge,Boying Gong,Rebecca K. Chance,Iain C. Macaulay,Hsin-jung Chou,Russell B. Fletcher,Diya Das,Kelly Street,Hector Roux de Bézieux,Yoon Gi Choi,Davide Risso,Sandrine Dudoit,Elizabeth Purdom,Jonathan Mill,Ralph Abi Hachem,Hiroaki Matsunami,Darren W. Logan,Bradley J. Goldstein,Matthew S. Grubb,John Ngai,John Ngai,Sandeep Robert Datta +25 more
TL;DR: Findings suggest that CoV-2 infection of non-neuronal cell types leads to anosmia and related disturbances in odor perception in COVID-19 patients.
Journal ArticleDOI
A circuit from hippocampal CA2 to lateral septum disinhibits social aggression.
Felix Leroy,Jung M. Park,Arun Asok,David H. Brann,Torcato Meira,Torcato Meira,Lara M. Boyle,Eric W. Buss,Eric R. Kandel,Eric R. Kandel,Steven A. Siegelbaum +10 more
TL;DR: It is reported that pyramidal neurons in the CA2 region of the hippocampus, which are important for social memory, promote social aggression in mice via a disinhibitory circuit involving the lateral septum and ventromedial hypothalamus.