N
Niccolo Bolli
Researcher at University of Milan
Publications - 157
Citations - 18277
Niccolo Bolli is an academic researcher from University of Milan. The author has contributed to research in topics: Multiple myeloma & Medicine. The author has an hindex of 40, co-authored 133 publications receiving 14204 citations. Previous affiliations of Niccolo Bolli include University of Cambridge & Harvard University.
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Journal ArticleDOI
Signatures of mutational processes in human cancer
Ludmil B. Alexandrov,Serena Nik-Zainal,Serena Nik-Zainal,David C. Wedge,Samuel Aparicio,Sam Behjati,Sam Behjati,Andrew V. Biankin,Graham R. Bignell,Niccolo Bolli,Niccolo Bolli,Åke Borg,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Sandrine Boyault,Birgit Burkhardt,Adam Butler,Carlos Caldas,Helen Davies,Christine Desmedt,Roland Eils,Jorunn E. Eyfjord,John A. Foekens,Mel Greaves,Fumie Hosoda,Barbara Hutter,Tomislav Ilicic,Sandrine Imbeaud,Sandrine Imbeaud,Marcin Imielinsk,Natalie Jäger,David T. W. Jones,David T. Jones,Stian Knappskog,Stian Knappskog,Marcel Kool,Sunil R. Lakhani,Carlos López-Otín,Sancha Martin,Nikhil C. Munshi,Nikhil C. Munshi,Hiromi Nakamura,Paul A. Northcott,Marina Pajic,Elli Papaemmanuil,Angelo Paradiso,John V. Pearson,Xose S. Puente,Keiran Raine,Manasa Ramakrishna,Andrea L. Richardson,Andrea L. Richardson,Julia Richter,Philip Rosenstiel,Matthias Schlesner,Ton N. Schumacher,Paul N. Span,Jon W. Teague,Yasushi Totoki,Andrew Tutt,Rafael Valdés-Mas,Marit M. van Buuren,Laura van ’t Veer,Anne Vincent-Salomon,Nicola Waddell,Lucy R. Yates,Icgc PedBrain,Jessica Zucman-Rossi,Jessica Zucman-Rossi,P. Andrew Futreal,Ultan McDermott,Peter Lichter,Matthew Meyerson,Matthew Meyerson,Sean M. Grimmond,Reiner Siebert,Elias Campo,Tatsuhiro Shibata,Stefan M. Pfister,Stefan M. Pfister,Peter J. Campbell,Peter J. Campbell,Peter J. Campbell,Michael R. Stratton,Michael R. Stratton +84 more
TL;DR: It is shown that hypermutation localized to small genomic regions, ‘kataegis’, is found in many cancer types, and this results reveal the diversity of mutational processes underlying the development of cancer.
Journal ArticleDOI
Genomic Classification and Prognosis in Acute Myeloid Leukemia
Elli Papaemmanuil,Moritz Gerstung,Lars Bullinger,Verena I. Gaidzik,Peter Paschka,Nicola D. Roberts,Nicola E. Potter,Michael Heuser,Felicitas Thol,Niccolo Bolli,Gunes Gundem,Peter Van Loo,Inigo Martincorena,Peter Ganly,Laura Mudie,Stuart McLaren,Sarah O’Meara,Keiran Raine,David R. Jones,Jon W. Teague,Adam Butler,Mel Greaves,Arnold Ganser,Konstanze Döhner,Richard F. Schlenk,Hartmut Döhner,Peter J. Campbell +26 more
TL;DR: The driver landscape in AML reveals distinct molecular subgroups that reflect discrete paths in the evolution of AML, informing disease classification and prognostic stratification.
Journal ArticleDOI
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma
Niccolo Bolli,Hervé Avet-Loiseau,David C. Wedge,Peter Van Loo,Ludmil B. Alexandrov,Inigo Martincorena,Kevin J. Dawson,Francesco Iorio,Serena Nik-Zainal,Graham R. Bignell,Jonathan Hinton,Yang Li,Jose M. C. Tubio,Stuart McLaren,Sarah O' Meara,Adam Butler,Jon W. Teague,Laura Mudie,Elizabeth Anderson,Naim U. Rashid,Yu-Tzu Tai,Masood A. Shammas,Adam S. Sperling,Mariateresa Fulciniti,Paul G. Richardson,Giovanni Parmigiani,Florence Magrangeas,Stephane Minvielle,Philippe Moreau,Michel Attal,Thierry Facon,P. Andrew Futreal,Kenneth C. Anderson,Peter J. Campbell,Nikhil C. Munshi +34 more
TL;DR: The myeloma genome is heterogeneous across the cohort, and exhibits diversity in clonal admixture and in dynamics of evolution, which may impact prognostic stratification, therapeutic approaches and assessment of disease response to treatment.
Journal ArticleDOI
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
Young Seok Ju,Ludmil B. Alexandrov,Moritz Gerstung,Inigo Martincorena,Serena Nik-Zainal,Manasa Ramakrishna,Helen Davies,Elli Papaemmanuil,Gunes Gundem,Adam Shlien,Niccolo Bolli,Sam Behjati,Patrick S. Tarpey,Jyoti Nangalia,Charles E. Massie,Adam Butler,Jon W. Teague,George S. Vassiliou,Anthony R. Green,Du M-Q.,Ashwin Unnikrishnan,John E. Pimanda,Bin Tean Teh,Nikhil C. Munshi,Mel Greaves,Paresh Vyas,Adel K. El-Naggar,Tom Santarius,V P Collins,Richard Grundy,Jack A. Taylor,David N. Hayes,David Malkin,Christopher S. Foster,Anne Y. Warren,Hayley C. Whitaker,Daniel Brewer,Rosalind A. Eeles,Colin Cooper,David E. Neal,Tapio Visakorpi,W. Isaacs,G. S. Bova,Adrienne M. Flanagan,P A Futreal,Andy G. Lynch,Patrick F. Chinnery,Ultan McDermott,Michael R. Stratton,Peter J. Campbell +49 more
TL;DR: This study analyzed somatic alterations in mtDNA from 1675 tumors and identified 1907 somatic substitutions, which exhibited dramatic replicative strand bias, predominantly C > T and A > G on the mitochondrial heavy strand.
Journal ArticleDOI
Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes
Jose M. C. Tubio,Yang Li,Young Seok Ju,Inigo Martincorena,Susanna L. Cooke,Marta Tojo,Gunes Gundem,Christodoulos P. Pipinikas,Jorge Zamora,Keiran Raine,Andrew Menzies,Pablo Román-García,Anthony Fullam,Moritz Gerstung,Adam Shlien,Patrick S. Tarpey,Elli Papaemmanuil,Stian Knappskog,Stian Knappskog,Stian Knappskog,Peter Van Loo,Peter Van Loo,Manasa Ramakrishna,Helen Davies,John Marshall,David C. Wedge,Jon W. Teague,Adam Butler,Serena Nik-Zainal,Serena Nik-Zainal,Ludmil B. Alexandrov,Sam Behjati,Lucy R. Yates,Niccolo Bolli,Niccolo Bolli,Laura Mudie,Claire Hardy,Sancha Martin,Stuart McLaren,Sarah O’Meara,Elizabeth Anderson,Mark Maddison,Stephen J. Gamble,Christopher S. Foster,Anne Y. Warren,Hayley C. Whitaker,Daniel Brewer,Daniel Brewer,Rosalind A. Eeles,Colin Cooper,Colin Cooper,David E. Neal,Andy G. Lynch,Tapio Visakorpi,William B. Isaacs,Laura Van't Veer,Carlos Caldas,Christine Desmedt,Christos Sotiriou,Samuel Aparicio,John A. Foekens,Jorunn E. Eyfjord,Sunil R. Lakhani,Sunil R. Lakhani,Gilles Thomas,Ola Myklebost,Paul N. Span,Anne Lise Børresen-Dale,Andrea L. Richardson,Marc J. van de Vijver,Anne Vincent-Salomon,Gert Van den Eynden,Adrienne M. Flanagan,Adrienne M. Flanagan,P. Andrew Futreal,P. Andrew Futreal,Sam M. Janes,G. Steven Bova,Michael R. Stratton,Ultan McDermott,Peter J. Campbell,Peter J. Campbell +81 more
TL;DR: It is found that 3′ transduction activity in a patient’s tumor was always associated with hypomethylation of that element, and in some cases transduction events can scatter exons, genes, and regulatory elements widely across the genome.