D
David Roth
Researcher at University of Miami
Publications - 332
Citations - 15136
David Roth is an academic researcher from University of Miami. The author has contributed to research in topics: Transplantation & Kidney transplantation. The author has an hindex of 66, co-authored 329 publications receiving 14457 citations. Previous affiliations of David Roth include Baylor College of Medicine & New York University.
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Journal ArticleDOI
Grazoprevir plus elbasvir in treatment-naive and treatment-experienced patients with hepatitis C virus genotype 1 infection and stage 4-5 chronic kidney disease (the C-SURFER study): a combination phase 3 study.
David Roth,David R. Nelson,Annette Bruchfeld,AnnMarie Liapakis,Marcelo Silva,Howard Paul Monsour,Paul J. Martin,Stanislas Pol,Maria Carlota Londoño,Tarek Hassanein,Philippe J. Zamor,Eli Zuckerman,Shuyan Wan,Beth Jackson,Bach-Yen Nguyen,Michael N. Robertson,Eliav Barr,Janice Wahl,Wayne Greaves +18 more
TL;DR: Once-daily grazoprevir and elbasvir for 12 weeks had a low rate of adverse events and was effective in patients infected with HCV genotype 1 and stage 4-5 chronic kidney disease.
Journal ArticleDOI
Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction.
David Roth,John H. Wilson +1 more
TL;DR: Analysis of 199 independent junctional sequences from seven constructs with different mismatched ends indicates that single-stranded extensions are relatively stable in monkey cells and that the terminal few nucleotides are critical for cell-mediated end joining.
Journal ArticleDOI
Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice
Yansong Gu,Katherine J. Seidl,Gary Rathbun,Chengming Zhu,John P. Manis,Nienke van der Stoep,Laurie Davidson,Hwei Ling Cheng,JoAnn Sekiguchi,Karen M. Frank,Patricia Stanhope-Baker,Mark S. Schlissel,David Roth,Frederick W. Alt +13 more
TL;DR: Ku70, Ku80, and DNA-PKcs are subunits of the DNA-dependent protein kinase (DNA-PK), an enzyme implicated in DNA double-stranded break repair and V(D)J recombination, and Ku70-deficient cells were severely impaired for joining of V( D)J coding and recombination signal sequences.
Journal ArticleDOI
Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
TL;DR: It is suggested that Ku86 may be required to remodel or disassemble DNA-protein complexes containing broken ends, making them available for further processing and joining in V(D)J recombination in vivo.
Journal ArticleDOI
V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes.
TL;DR: The formation of hairpins at coding ends may be a universal, early step in V(D)J recombination; this would provide a simple explanation for the origin of P nucleotides in coding joints, and suggest a possible role for the scid factor.