D
David Santamaría
Researcher at University of Oviedo
Publications - 40
Citations - 4204
David Santamaría is an academic researcher from University of Oviedo. The author has contributed to research in topics: Cyclin-dependent kinase & Cell cycle. The author has an hindex of 23, co-authored 39 publications receiving 3677 citations. Previous affiliations of David Santamaría include Facultad de Filosofía y Letras.
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Journal ArticleDOI
Cdk1 is sufficient to drive the mammalian cell cycle
David Santamaría,Cédric Barrière,Cédric Barrière,Antonio Cerqueira,Sarah L. Hunt,Claudine Tardy,Kathryn Newton,Javier F. Cáceres,Pierre Dubus,Marcos Malumbres,Mariano Barbacid +10 more
TL;DR: It is shown that mouse embryos lacking all interphase Cdks undergo organogenesis and develop to midgestation and that in the absence of interphaseCdks, Cdk1 can execute all the events that are required to drive cell division.
Journal ArticleDOI
The timing and spatiotemporal patterning of Neanderthal disappearance
Thomas Higham,Katerina Douka,Rachel Wood,Christopher Bronk Ramsey,Fiona Brock,Laura Basell,Marta Camps,Alvaro Arrizabalaga,Javier Baena,Cecillio Barroso-Ruíz,Christopher A. Bergman,Coralie Boitard,Paolo Boscato,Miguel Caparrós,Nicholas J. Conard,Christelle Draily,Alain Froment,Bertila Galván,Paolo Gambassini,Alejandro García-Moreno,Stefano Grimaldi,Paul Haesaerts,Brigitte Holt,María-José Iriarte-Chiapusso,Arthur J. Jelinek,Jesús Francisco Jordá Pardo,José-Manuel Maíllo-Fernández,Anat Marom,Julià Maroto,Mario Menéndez,Laure Metz,Eugène Morin,Adriana Moroni,Fabio Negrino,Eleni Panagopoulou,Marco Peresani,Stéphane Pirson,Marco de la Rasilla,Julien Riel-Salvatore,Annamaria Ronchitelli,David Santamaría,Patrick Semal,Ludovic Slimak,Joaquim Soler,Narcís Soler,Aritza Villaluenga,Ron Pinhasi,Roger Jacobi +47 more
TL;DR: Improved accelerator mass spectrometry 14C techniques are applied to construct robust chronologies from 40 key Mousterian and Neanderthal archaeological sites, showing that there was ample time for the transmission of cultural and symbolic behaviours, as well as possible genetic exchanges, between the two groups.
Journal ArticleDOI
A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma
Marta Puyol,Alberto Martín,Pierre Dubus,Francisca Mulero,Pilar Pizcueta,Gulfaraz Khan,Carmen Guerra,David Santamaría,Mariano Barbacid +8 more
TL;DR: Targeting Cdk4 alleles in advanced tumors detectable by computed tomography scanning also induces senescence and prevents tumor progression, suggesting that robust and selective pharmacological inhibition of Cdk 4 may provide therapeutic benefit for NSCLC patients carrying K-RAS oncogene.
Journal ArticleDOI
Neanderthal medics? Evidence for food, cooking, and medicinal plants entrapped in dental calculus
Karen Hardy,Stephen Buckley,Matthew J. Collins,Almudena Estalrrich,Don Brothwell,Les Copeland,Antonio García-Tabernero,Samuel García-Vargas,Marco de la Rasilla,Carles Lalueza-Fox,Rosa Huguet,Markus Bastir,David Santamaría,Marco Madella,Julie Wilson,Ángel Fernández Cortés,Antonio Rosas +16 more
TL;DR: The varied use of plants that are identified suggests that the Neanderthal occupants of El Sidrón had a sophisticated knowledge of their natural surroundings which included the ability to select and use certain plants.
Journal ArticleDOI
c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma
Rafael B. Blasco,Sarah Francoz,David Santamaría,Marta Cañamero,Pierre Dubus,Jean Charron,Manuela Baccarini,Mariano Barbacid +7 more
TL;DR: Results indicate that c-Raf plays a unique role in mediating K-Ras signaling and makes it a suitable target for therapeutic intervention.