David Schafflick

TL;DR: A single-cell characterization of cerebrospinal fluid and blood of newly diagnosed multiple sclerosis patients is provided, revealing altered composition of lymphocyte and monocyte subsets, validated by other methods including the interrogation of the TFH subset in mouse models of MS.

TL;DR: Based on single-cell transcriptomics, this article identified a highly location-specific composition and expression profile of tissue-resident leukocytes in CNS parenchyma, pia-enriched subdural meninges, dura mater, choroid plexus and cerebrospinal fluid.

TL;DR: Current understanding of antigenic targets and the relevance of new immunological concepts for inflammatory neuropathies are summarized and the gap between pre-clinical and clinical findings is illustrated and future directions of development are outlined.

TL;DR: In this article , a unique phenotype of myeloid cells exclusive to the brain after stroke was discovered, which partially resemble neurodegenerative disease-associated microglia and exhibit a lipid-phagocytosing phenotype.

TL;DR: In this article , a unique phenotype of myeloid cells exclusive to the brain after stroke was discovered, which partially resemble neurodegenerative disease-associated microglia and exhibit a lipid-phagocytosing phenotype.