Chenling Xu

TL;DR: Three replicate hybrid populations that formed naturally between two swordtail fish species are studied, estimating their fine-scale genetic map and inferring ancestry along the genomes of 690 individuals and indicate that selection on swordtail hybrids stems predominantly from deleterious combinations of epistatically interacting alleles.

TL;DR: A single-cell characterization of cerebrospinal fluid and blood of newly diagnosed multiple sclerosis patients is provided, revealing altered composition of lymphocyte and monocyte subsets, validated by other methods including the interrogation of the TFH subset in mouse models of MS.

TL;DR: In this paper, the authors proposed a semi-supervised variant of scVI, called single-cell ANnotation using Variational Inference (scANVI), to leverage existing cell state annotations.

TL;DR: SymSim is presented, a simulator that explicitly models the processes that give rise to data observed in single cell RNA-Seq experiments and can be used for benchmarking methods for clustering, differential expression and trajectory inference, and for examining the effects of various parameters on their performance.