Michael Heming

TL;DR: A single-cell characterization of cerebrospinal fluid and blood of newly diagnosed multiple sclerosis patients is provided, revealing altered composition of lymphocyte and monocyte subsets, validated by other methods including the interrogation of the TFH subset in mouse models of MS.

TL;DR: It is demonstrated that PPAR-γ exerts anti-inflammatory activities and shapes macrophage functions and identified a molecular link between GC and PPar-γ and could show for the first time that PP AR-γ modulates GC-induced migration in macrophages.

TL;DR: In this paper, single-cell sequencing was used to examine the immune cell profiles from the cerebrospinal fluid (CSF) of Neuro-COVID patients compared with patients with non-inflammatory and autoimmune neurological diseases or with viral encephalitis.

TL;DR: This study identifies subtypes and cell-type markers of PNS cells and a partially conserved autoimmunity module induced in glia cells, indicating common immunological features across different parts of the nervous system.

TL;DR: Based on single-cell transcriptomics, this article identified a highly location-specific composition and expression profile of tissue-resident leukocytes in CNS parenchyma, pia-enriched subdural meninges, dura mater, choroid plexus and cerebrospinal fluid.