D
David Zagzag
Researcher at New York University
Publications - 286
Citations - 29662
David Zagzag is an academic researcher from New York University. The author has contributed to research in topics: Glioma & Angiogenesis. The author has an hindex of 75, co-authored 280 publications receiving 27272 citations. Previous affiliations of David Zagzag include University of York & Hebrew University of Jerusalem.
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Journal ArticleDOI
Prediction of central nervous system embryonal tumour outcome based on gene expression
Scott L. Pomeroy,Pablo Tamayo,Michelle Gaasenbeek,Lisa Marie Sturla,Michael Angelo,Margaret McLaughlin,John Y.H. Kim,Liliana Goumnerova,Peter McL. Black,Ching C. Lau,Jeffrey C. Allen,David Zagzag,James M. Olson,Tom Curran,Cynthia Wetmore,Jaclyn A. Biegel,Tomaso Poggio,Shayan Mukherjee,Ryan Rifkin,Andrea Califano,Gustavo Stolovitzky,David N. Louis,Jill P. Mesirov,Eric S. Lander,Todd R. Golub,Todd R. Golub +25 more
TL;DR: It is demonstrated that medulloblastomas are molecularly distinct from other brain tumours including primitive neuroectodermal tumours, atypical teratoid/rhabdoid tumours (AT/RTs) and malignant gliomas, and it is shown that the clinical outcome of children with medullOBlastomas is highly predictable on the basis of the gene expression profiles of their tumours at diagnosis.
Journal Article
Overexpression of Hypoxia-inducible Factor 1α in Common Human Cancers and Their Metastases
Hua Zhong,Angelo M. De Marzo,Erik Laughner,Michael Lim,David A Hilton,David Zagzag,Peter Buechler,William B. Isaacs,Gregg L. Semenza,Jonathan W. Simons +9 more
TL;DR: The first clinical data indicating that HIF-1alpha may play an important role in human cancer progression are provided, indicating adaptations to a hypoxic microenvironment that are correlated with tumor invasion, metastasis, and lethality.
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Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF
Jocelyn Holash,Maisonpierre Peter C,Debra L Compton,Patricia Boland,C. R. Alexander,David Zagzag,George D. Yancopoulos,Stanley J. Wiegand +7 more
TL;DR: Evidence is presented here that a subset of tumors instead initially grows by coopting existing host vessels and regresses, leading to a secondarily avascular tumor and massive tumor cell loss.
Journal Article
Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging
Meng Law,Stanley Yang,Hao Wang,James S. Babb,James S. Babb,Glyn Johnson,Soonmee Cha,Edmond A. Knopp,David Zagzag +8 more
TL;DR: The rCBV measurements had the most superior diagnostic performance (either with or without metabolite ratios) in predicting glioma grade and can be used in a clinical setting to evaluate tumors preoperatively for histologic grade and provide a means for guiding treatment and predicting postoperative patient outcome.
Journal ArticleDOI
Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts
David Lyden,Alison Z. Young,David Zagzag,Wei Yan,William L. Gerald,Richard J. O'Reilly,Bernhard L. Bader,Richard O. Hynes,Yuan Zhuang,Katia Manova,Robert Benezra +10 more
TL;DR: Targeted disruption of the dominant negative helix–loop–helix proteins Id1 and Id3 in mice results in premature withdrawal of neuroblasts from the cell cycle and expression of neural-specific differentiation markers, which are required to maintain the timing of neuronal differentiation in the embryo and invasiveness of the vasculature.