D
David Zagzag
Researcher at New York University
Publications - 286
Citations - 29662
David Zagzag is an academic researcher from New York University. The author has contributed to research in topics: Glioma & Angiogenesis. The author has an hindex of 75, co-authored 280 publications receiving 27272 citations. Previous affiliations of David Zagzag include University of York & Hebrew University of Jerusalem.
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Journal ArticleDOI
ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma.
Sylwia Ammoun,Clare H. Cunliffe,Jeffrey C. Allen,Luis Chiriboga,Filippo G. Giancotti,David Zagzag,C. Oliver Hanemann,Matthias A. Karajannis +7 more
TL;DR: It is concluded that EGFR family receptor activation is a consistent feature of both sporadic and NF2-related VS, and molecular targeted therapy with lapatinib downregulates survivin and has antiproliferative activity in a preclinical VS model.
Journal ArticleDOI
Receptor protein tyrosine phosphatase α is essential for hippocampal neuronal migration and long-term potentiation
Angiola Petrone,Fortunato Battaglia,Fortunato Battaglia,Cheng Wang,Adina Dusa,Jing Su,David Zagzag,Riccardo Bianchi,Patrizia Casaccia-Bonnefil,Ottavio Arancio,Ottavio Arancio,Jan Sap +11 more
TL;DR: It is reported that absence of RPTPα compromises correct positioning of pyramidal neurons during development of mouse hippocampus, and is identified as a novel member of the functional class of genes that control radial neuronal migration.
Journal ArticleDOI
High-grade glioma before and after treatment with radiation and Avastin: Initial observations
Ingeborg Fischer,Clare H. Cunliffe,Robert J. Bollo,Shahzad Raza,David Monoky,Luis Chiriboga,Erik C. Parker,John G. Golfinos,Patrick J. Kelly,Edmond A. Knopp,Michael L. Gruber,David Zagzag,Ashwatha Narayana +12 more
TL;DR: It is concluded that a change in vascular morphology can be observed following antiangiogenic treatment, and there seems to be no correlation between VEGF-A expression and clinical parameters.
Journal ArticleDOI
Medulloblastoma subgroups remain stable across primary and metastatic compartments
Xin Wang,Adrian M. Dubuc,Vijay Ramaswamy,Stephen C. Mack,Deena M.A. Gendoo,Marc Remke,Xiaochong Wu,Livia Garzia,Betty Luu,Florence M.G. Cavalli,John Peacock,Borja López,Patryk Skowron,David Zagzag,David Lyden,Caitlin Hoffman,Yoon Jae Cho,Charles G. Eberhart,Tobey J. MacDonald,Xiao-Nan Li,Timothy E. Van Meter,Paul A. Northcott,Benjamin Haibe-Kains,Benjamin Haibe-Kains,Cynthia Hawkins,James T. Rutka,Eric Bouffet,Stefan M. Pfister,Andrey Korshunov,Michael D. Taylor +29 more
TL;DR: The hypothesis that medulloblastoma subgroups arise from distinct cells of origin, which are carried forward from ontogeny to oncology is supported, as are the findings of this investigation.
Journal ArticleDOI
Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2.
Aram S. Modrek,Danielle Golub,Themasap Khan,Devin Bready,Jod Prado,Christopher Bowman,Jingjing Deng,Guoan Zhang,Pedro P. Rocha,Ramya Raviram,Charalampos Lazaris,James M. Stafford,Gary LeRoy,Michael Kader,Joravar Dhaliwal,N. Sumru Bayin,Joshua D. Frenster,Jonathan Serrano,Luis Chiriboga,Rabaa Baitalmal,Gouri Nanjangud,Andrew S. Chi,John G. Golfinos,Jing Wang,Matthias A. Karajannis,Richard Bonneau,Danny Reinberg,Danny Reinberg,Aristotelis Tsirigos,David Zagzag,Matija Snuderl,Jane A. Skok,Thomas A. Neubert,Dimitris G. Placantonakis +33 more
TL;DR: The human model of IDH mutant LGA formation implicates impaired NSC differentiation because of repression of SOX2 as an early driver of gliomagenesis.