Davneet S. Minhas

TL;DR: A working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls and typical Alzheimer's disease patients.

TL;DR: A kinematic model for needle steering via duty-cycled spinning during needle insertion provides proportional control of the curvature of the needle trajectory through tissue.

TL;DR: The within-individual examination suggests three sequential phases in the development of autosomal dominant Alzheimer's disease-active amyloidosis, a stable amyloids-positive period, and progressive neurodegeneration and cognitive decline-indicating that Aβ accumulation is largely complete before progressive neuro degeneration and Cognitive decline occur.

TL;DR: The results suggest that resting-state CBF is a marker of CMB-related small-vessel disease and in cognitively normal elderly individuals, incidental CMBs in cortical locations are associated with widespread reductions in resting- state CBF.

TL;DR: The accuracy of the needle-steering system was demonstrated in a cadaveric model and the safety of the device in vivo, and the development of an inexpensive system for flexible percutaneous intracranial navigation may be of significant clinical benefit.