The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET
William E. Klunk,William E. Klunk,Robert A. Koeppe,Julie C. Price,Tammie L.S. Benzinger,Tammie L.S. Benzinger,Michael D. Devous,William J. Jagust,Keith A. Johnson,Chester A. Mathis,Davneet S. Minhas,Michael J. Pontecorvo,Christopher C. Rowe,Daniel Skovronsky,Mark A. Mintun +14 more
TLDR
A working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls and typical Alzheimer's disease patients.Abstract:
Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (≤45 years) and typical Alzheimer's disease patients. The units of this scale have been named "Centiloids." Basically, we describe a "standard" method of analyzing PiB PET data and then a method for scaling any "nonstandard" method of PiB PET analysis (or any other tracer) to the Centiloid scale.read more
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NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease
Clifford R. Jack,David A. Bennett,Kaj Blennow,Maria C. Carrillo,Billy Dunn,Samantha Budd Haeberlein,David M. Holtzman,William J. Jagust,Frank Jessen,Jason Karlawish,Enchi Liu,José Luis Molinuevo,Thomas J. Montine,Creighton H. Phelps,Katherine P. Rankin,Christopher C. Rowe,Philip Scheltens,Eric Siemers,Heather M. Snyder,Reisa A. Sperling,Cerise L Elliott,Eliezer Masliah,Laurie M. Ryan,Nina Silverberg +23 more
TL;DR: This research framework seeks to create a common language with which investigators can generate and test hypotheses about the interactions among different pathologic processes (denoted by biomarkers) and cognitive symptoms and envision that defining AD as a biological construct will enable a more accurate characterization and understanding of the sequence of events that lead to cognitive impairment that is associated with AD.
Journal ArticleDOI
Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria.
Bruno Dubois,Harald Hampel,Harald Hampel,Howard Feldman,Philip Scheltens,Paul S. Aisen,Sandrine Andrieu,Hovagim Bakardjian,Habib Benali,Lars Bertram,Lars Bertram,Kaj Blennow,Karl Broich,Enrica Cavedo,Sebastian J. Crutch,Jean-François Dartigues,Charles Duyckaerts,Stéphane Epelbaum,Giovanni B. Frisoni,Serge Gauthier,Remy Genthon,Alida A. Gouw,Alida A. Gouw,Marie-Odile Habert,David M. Holtzman,Miia Kivipelto,Miia Kivipelto,Simone Lista,José Luis Molinuevo,Sid E. O'Bryant,Gil D. Rabinovici,Christopher C. Rowe,Stephen Salloway,Lon S. Schneider,Reisa A. Sperling,Reisa A. Sperling,Marc Teichmann,Maria C. Carrillo,Jeffrey L. Cummings,Cliff R. Jack +39 more
TL;DR: An updated review of the literature and evidence on the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage of Alzheimer's disease are provided.
Journal ArticleDOI
A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers
Clifford R. Jack,David A. Bennett,Kaj Blennow,Maria C. Carrillo,Howard Feldman,Giovanni B. Frisoni,Harald Hampel,William J. Jagust,Keith A. Johnson,David S. Knopman,Ronald C. Petersen,Philip Scheltens,Reisa A. Sperling,Bruno Dubois +13 more
TL;DR: This work proposes the “A/T/N” system, a descriptive system for categorizing multidomain biomarker findings at the individual person level in a format that is easy to understand and use and suited to population studies of cognitive aging.
Journal ArticleDOI
Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity
Sebastian Palmqvist,Michael Schöll,Michael Schöll,Olof Strandberg,Niklas Mattsson,Erik Stomrud,Henrik Zetterberg,Henrik Zetterberg,Henrik Zetterberg,Kaj Blennow,Kaj Blennow,Susan M. Landau,William J. Jagust,Oskar Hansson +13 more
TL;DR: It is suggested that Aβ fibrils start to accumulate predominantly within certain parts of the DMN in preclinical AD and already then affect brain connectivity before neurodegeneration occurs.
Journal ArticleDOI
Defining imaging biomarker cut points for brain aging and Alzheimer's disease
Clifford R. Jack,Heather J. Wiste,Stephen D. Weigand,Terry M. Therneau,Val J. Lowe,David S. Knopman,Jeffrey L. Gunter,Matthew L. Senjem,David T.W. Jones,Kejal Kantarci,Mary M. Machulda,Michelle M. Mielke,Rosebud O. Roberts,Prashanthi Vemuri,Denise A. Reyes,Ronald C. Petersen +15 more
TL;DR: The goal was to develop cut points for amyloid positron emission tomography (PET), tau PET, flouro‐deoxyglucose (FDG) PET, and MRI cortical thickness.
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