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Eric McDade
Researcher at Washington University in St. Louis
Publications - 203
Citations - 12313
Eric McDade is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Medicine & Alzheimer's disease. The author has an hindex of 42, co-authored 142 publications receiving 9013 citations. Previous affiliations of Eric McDade include University of Washington & University of California, San Francisco.
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Journal ArticleDOI
Clinical and Biomarker Changes in Dominantly Inherited Alzheimer’s Disease
Randall J. Bateman,Chengjie Xiong,Tammie L.S. Benzinger,Anne M. Fagan,Alison Goate,Nick C. Fox,Daniel S. Marcus,Nigel J. Cairns,Xianyun Xie,Tyler Blazey,David M. Holtzman,Anna Santacruz,Virginia Buckles,Angela Oliver,Krista L. Moulder,Paul S. Aisen,Bernardino Ghetti,William E. Klunk,Eric McDade,Ralph N. Martins,Colin L. Masters,Richard Mayeux,John M. Ringman,Martin N. Rossor,Peter R. Schofield,Reisa A. Sperling,Stephen Salloway,John C. Morris +27 more
TL;DR: In this paper, a longitudinal study of 128 patients with Alzheimer's disease was conducted, where the authors used the participant's age at baseline assessment and the parent's age to calculate the estimated years from expected symptom onset (age of the participant minus parent's ages at symptom onset).
Journal Article
Clinical and biomarker changes in dominantly inherited alzheimer's disease
Peter R. Schofield,Randall J. Bateman,Chengjie Xiong,Tls Benzinger,Anne M. Fagan,Alison Goate,Nick C. Fox,Daniel S. Marcus,Nigel J. Cairns,X Xie,Tyler Blazey,David M. Holtzman,Anna Santacruz,Virginia Buckles,Angela Oliver,Krista L. Moulder,Paul S. Aisen,Bernardino Ghetti,William E. Klunk,Eric McDade,Ralph N. Martins,Colin L. Masters,Richard Mayeux,John M. Ringman,Martin N. Rossor,Reisa A. Sperling,Stephen Salloway,John C. Morris +27 more
TL;DR: It is found that autosomal dominant Alzheimer's disease was associated with a series of pathophysiological changes over decades in CSF biochemical markers of Alzheimer’s disease, brain amyloid deposition, and brain metabolism as well as progressive cognitive impairment.
Journal ArticleDOI
Normative spatiotemporal gait parameters in older adults
TL;DR: In this article, a factor analysis was performed on nearly two dozen spatiotemporal gait parameters from healthy, able-bodied men and women over the age of 70, using data from 294 participants enrolled in the Mayo Clinic Study of Aging.
Journal ArticleDOI
Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease
Oliver Preische,Oliver Preische,Stephanie A. Schultz,Anja Apel,Anja Apel,Jens Kuhle,Stephan A. Kaeser,Stephan A. Kaeser,Christian Barro,Susanne Gräber,Elke Kuder-Buletta,Christian LaFougere,Christoph Laske,Christoph Laske,Jonathan Vöglein,Jonathan Vöglein,Johannes Levin,Johannes Levin,Colin L. Masters,Ralph N. Martins,Peter R. Schofield,Peter R. Schofield,Martin N. Rossor,Neill R. Graff-Radford,Stephen Salloway,Bernardino Ghetti,John M. Ringman,James M. Noble,Jasmeer P. Chhatwal,Alison Goate,Tammie L.S. Benzinger,John C. Morris,Randall J. Bateman,Guoqiao Wang,Anne M. Fagan,Eric McDade,Brian A. Gordon,Mathias Jucker,Mathias Jucker +38 more
TL;DR: Serum NfL dynamics in serum predict disease progression and brain neurodegeneration at the early presymptomatic stages of familial Alzheimer’s disease, which supports its potential utility as a clinically useful biomarker.
Journal ArticleDOI
Symptom onset in autosomal dominant Alzheimer disease: A systematic review and meta-analysis
Davis C. Ryman,Natalia Acosta-Baena,Paul S. Aisen,Thomas D. Bird,Adrian Danek,Nick C. Fox,Alison Goate,Peter Frommelt,Bernardino Ghetti,Jessica B. Langbaum,Francisco Lopera,Ralph N. Martins,Colin L. Masters,Richard Mayeux,Eric McDade,Sonia Moreno,Eric M. Reiman,John M. Ringman,Steve Salloway,Peter R. Schofield,Reisa A. Sperling,Pierre N. Tariot,Chengjie Xiong,John C. Morris,Randall J. Bateman +24 more
TL;DR: Strong and highly significant correlations between individual age at symptom onset and predicted values based on parental age at onset and mean ages at onset by mutation type and family are discovered, which persist after controlling for APOE genotype and sex.