D
Dean J. Naylor
Researcher at Max Planck Society
Publications - 4
Citations - 1037
Dean J. Naylor is an academic researcher from Max Planck Society. The author has contributed to research in topics: GroES & Chaperonin. The author has an hindex of 4, co-authored 4 publications receiving 977 citations.
Papers
More filters
Journal ArticleDOI
Proteome-wide Analysis of Chaperonin-Dependent Protein Folding in Escherichia coli
Michael J. Kerner,Dean J. Naylor,Yasushi Ishihama,Tobias Maier,Hung-Chun Chang,Anna P. Stines,Costa Georgopoulos,Dmitrij Frishman,Manajit Hayer-Hartl,Matthias Mann,F. Ulrich Hartl +10 more
TL;DR: It is suggested that the chaperonin system may have facilitated the evolution of this fold into a versatile platform for the implementation of numerous enzymatic functions.
Journal ArticleDOI
Dual Function of Protein Confinement in Chaperonin-Assisted Protein Folding
Achim Brinker,Günter Pfeifer,Michael J. Kerner,Dean J. Naylor,Franz-Ulrich Hartl,Manajit Hayer-Hartl +5 more
TL;DR: It is shown that the cage formed by GroEL and its cofactor GroES can have a dual role in promoting folding, and confinement of unfolded protein in the narrow hydrophilic space of the chaperonin cage smoothes the energy landscape for the folding of some proteins.
Journal ArticleDOI
Coexistence of group I and group II chaperonins in the archaeon Methanosarcina mazei
Daniel Klunker,Bernd Haas,Angela Hirtreiter,Luis Figueiredo,Dean J. Naylor,Günter Pfeifer,Volker Müller,Uwe Deppenmeier,Gerhard Gottschalk,F. Ulrich Hartl,Manajit Hayer-Hartl +10 more
TL;DR: The co-existence of both chaperonin systems in the same cellular compartment suggests the Methanosarcina species as useful model systems in studying the differential substrate specificity of the group I and II chaperOnins and in elucidating how newly synthesized proteins are sorted from the ribosome to the proper chaper onin for folding.
Journal ArticleDOI
Functional Characterization of an Archaeal GroEL/GroES Chaperonin System SIGNIFICANCE OF SUBSTRATE ENCAPSULATION
Luis Figueiredo,Daniel Klunker,Debbie Ang,Dean J. Naylor,Michael J. Kerner,Costa Georgopoulos,F. Ulrich Hartl,Manajit Hayer-Hartl +7 more
TL;DR: A detailed functional analysis of the archaeal GroEL/GroES system of Methanosarcina mazei (Mm) in comparison to its bacterial counterpart from Escherichia coli (Ec) indicates that the basic encapsulation mechanism of bacterial GroEL has been preserved and suggests that it has adjusted the length of its reaction cycle to the slower growth rates of Archaea.