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Rebecca C. Taylor
Researcher at Laboratory of Molecular Biology
Publications - 35
Citations - 6816
Rebecca C. Taylor is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Proteostasis & Unfolded protein response. The author has an hindex of 14, co-authored 30 publications receiving 5977 citations. Previous affiliations of Rebecca C. Taylor include Salk Institute for Biological Studies & University of California, Berkeley.
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Journal ArticleDOI
Apoptosis: controlled demolition at the cellular level
TL;DR: This work has shown that during the demolition phase of apoptosis, members of the caspase family of cysteine proteases target several hundred proteins for restricted proteolysis in a controlled manner that minimizes damage and disruption to neighbouring cells and avoids the release of immunostimulatory molecules.
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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Daniel F. Egan,David B. Shackelford,Maria M. Mihaylova,Sara Gelino,Rebecca A. Kohnz,William B. Mair,Debbie S. Vasquez,Aashish Joshi,Dana M. Gwinn,Rebecca C. Taylor,John M. Asara,James A. J. Fitzpatrick,Andrew Dillin,Benoit Viollet,Mondira Kundu,Malene Hansen,Reuben J. Shaw +16 more
TL;DR: Reconstitution of ULK1-deficient cells with a mutant ULK2 that cannot be phosphorylated by AMPK revealed that such phosphorylation is required for mitochondrial homeostasis and cell survival during starvation.
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Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
Alexander U. Lüthi,Sean P. Cullen,Edel A. McNeela,Patrick J. Duriez,Inna S. Afonina,Clare Sheridan,Gabriela Brumatti,Rebecca C. Taylor,Kristof Kersse,Peter Vandenabeele,Ed C. Lavelle,Seamus J. Martin +11 more
TL;DR: It is shown that IL-33 was processed by caspases activated during apoptosis but was not a physiological substrate for caspasing associated with inflammation, and caspase-mediated proteolysis acts as a switch to dampen the proinflammatory properties of IL- 33.
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XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity
Rebecca C. Taylor,Andrew Dillin +1 more
TL;DR: A secreted ER stress signal (SERSS) that promotes ER stress resistance and longevity, and the release of neurotransmitters is required for this intertissue signaling event.
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Aging as an Event of Proteostasis Collapse
Rebecca C. Taylor,Andrew Dillin +1 more
TL;DR: Metabolic signaling pathways that regulate the aging process, mediated by insulin/IGF-1 signaling, dietary restriction, and reduced mitochondrial function, can modulate the proteostasis machinery in many ways to maintain a youthful proteome for longer and prevent the onset of age-associated diseases.