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Dennis Bruemmer

Researcher at University of Pittsburgh

Publications -  93
Citations -  5989

Dennis Bruemmer is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Receptor & Vascular smooth muscle. The author has an hindex of 39, co-authored 91 publications receiving 5295 citations. Previous affiliations of Dennis Bruemmer include Baylor College of Medicine & University of Kentucky.

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Journal ArticleDOI

NR4A Orphan Nuclear Receptors: Transcriptional Regulators of Gene Expression in Metabolism and Vascular Biology

Yue Zhao, +1 more
- 01 Aug 2010 - 
TL;DR: Recent advances in understanding the molecular biology and physiological functions of NR4A receptors are summarized and their role in the transcriptional control of metabolism and vascular remodeling is discussed.
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Intensive glycemic control and cardiovascular disease: an update.

Aparna Brown, +2 more
- 01 Jul 2010 - 
TL;DR: The effects of intensive glycemic control on cardiovascular disease are discussed, key differences in the design of these trials that might have contributed to their disparate findings are examined, and Recommendations from the current joint ADA, AHA, and ACCF position statement on intensive glyoglycemia are highlighted.
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Peroxisome Proliferator-Activated Receptor γ: Implications for Cardiovascular Disease

Willa A. Hsueh, +1 more
- 01 Feb 2004 - 
TL;DR: The peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily as mentioned in this paper.
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Osteopontin modulates angiotensin II- induced fibrosis in the intact murine heart

Alan R. Collins, +9 more
- 05 May 2004 - 
TL;DR: Osteopontin mediates cardiac fibrosis, probably through the modulation of cellular adhesion and proliferation, through the inhibition of angiotensin II in mice deficient in OPN.
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The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation.

Takashi Nomiyama, +8 more
- 03 Nov 2006 - 
TL;DR: It is demonstrated that SMC isolated from NOR1-deficient mice exhibit decreased cell proliferation and characterize cyclin D1 and D2 as NOR1 target genes in SMC, and further demonstrate that NOR1 functions as a key transcriptional regulator of SMC proliferation.