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Derek Boerboom
Researcher at Université de Montréal
Publications - 83
Citations - 3091
Derek Boerboom is an academic researcher from Université de Montréal. The author has contributed to research in topics: Wnt signaling pathway & Granulosa cell. The author has an hindex of 30, co-authored 78 publications receiving 2733 citations. Previous affiliations of Derek Boerboom include Baylor College of Medicine & National Institutes of Health.
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Journal ArticleDOI
WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse
Heather L. Franco,Daisy Dai,Kevin Y. Lee,Cory A. Rubel,Dennis R. Roop,Derek Boerboom,Jae Wook Jeong,John P. Lydon,Indrani C. Bagchi,Milan K. Bagchi,Francesco J. DeMayo +10 more
TL;DR: Analysis of Wnt4 expression in the adult uterus during pregnancy indicates that it may play a role in the regulation of endometrial stromal cell proliferation, survival, and differentiation, which is required to support the developing embryo.
Journal ArticleDOI
Misregulated Wnt/β-Catenin Signaling Leads to Ovarian Granulosa Cell Tumor Development
Derek Boerboom,Marilene Paquet,Minnie Hsieh,Jinsong Liu,Soazik P. Jamin,Richard R. Behringer,Jean Sirois,Makoto Mark Taketo,Jo Anne S. Richards +8 more
TL;DR: A causal link between misregulated Wnt/beta-catenin signaling and GCT development is shown and Amhr2(cre/+) mice provide a novel model system for the study of GCT biology.
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WNT4 is required for normal ovarian follicle development and female fertility
Alexandre Boyer,Evelyne Lapointe,Xiaofeng Zheng,Robert G. Cowan,Huaiguang Li,Susan M. Quirk,Francesco J. DeMayo,JoAnne S. Richards,Derek Boerboom,Derek Boerboom +9 more
TL;DR: RT-PCR analyses showed that WNT4 regulates the expression of Star, Cyp11a1, and Cyp19, steroidogenic genes previously identified as downstream targets of the WNT signaling effector CTNNB1, which indicates that Wnt4 is required for normal antral follicle development and may act by regulating granulosa cell functions including steroidogenesis.
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WNT signaling in ovarian follicle biology and tumorigenesis.
TL;DR: The current knowledge of WNT signaling in ovarian follicles is reviewed, highlighting both the great promise and the many unresolved questions of this emerging field of research.
Journal ArticleDOI
Mice Null for Frizzled4 (Fzd4−/−) Are Infertile and Exhibit Impaired Corpora Lutea Formation and Function
Minnie Hsieh,Derek Boerboom,Masayuki Shimada,Yuet Lo,Albert F. Parlow,Ulrich F O Luhmann,Wolfgang Berger,JoAnne S. Richards +7 more
TL;DR: This article showed that FZd4 appears to impact the formation of the corpus luteum by mechanisms that more closely phenocopy Prlr null mice, and Fzd4-/- mice fail to become pregnant and do not produce offspring.