D
Derek L. Buhl
Researcher at Pfizer
Publications - 32
Citations - 4616
Derek L. Buhl is an academic researcher from Pfizer. The author has contributed to research in topics: Hippocampus & Medicine. The author has an hindex of 17, co-authored 28 publications receiving 4112 citations. Previous affiliations of Derek L. Buhl include Massachusetts Institute of Technology & Rutgers University.
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Journal ArticleDOI
Communication between neocortex and hippocampus during sleep in rodents
TL;DR: A robust correlation of neuronal discharges between the somatosensory cortex and hippocampus on both slow and fine time scales in the mouse and rat is shown, suggesting that oscillation-mediated temporal links coordinate specific information transfer between neocortical and hippocampal cell assemblies.
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Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion
Toshiaki Nakashiba,Jesse D. Cushman,Kenneth A. Pelkey,Sophie Renaudineau,Derek L. Buhl,Thomas J. McHugh,Vanessa Rodriguez Barrera,Ramesh Chittajallu,Keisuke S. Iwamoto,Chris J. McBain,Michael S. Fanselow,Susumu Tonegawa +11 more
TL;DR: It is suggested that as adult-born GCs age, their function switches from pattern separation to rapid pattern completion, and older GCs contribute to the rapid recall by pattern completion.
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Transgenic Inhibition of Synaptic Transmission Reveals Role of CA3 Output in Hippocampal Learning
TL;DR: A generally applicable tetanus toxin–based method for transgenic mice that permits inducible and reversible inhibition of synaptic transmission and applied it to the trisynaptic pathway is developed and it is found that synaptic output from CA3 in the transexual pathway is dispensable and the short monosynaptic pathways is sufficient for incremental spatial learning.
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Hippocampal network patterns of activity in the mouse
György Buzsáki,Derek L. Buhl,Kenneth D. Harris,Jozsef Csicsvari,Boldizsár Czéh,Alexei Morozov +5 more
TL;DR: The electrical patterns in the behaving animal are investigated using multisite silicon probes and wire tetrodes and it is suggested that the main hippocampal network patterns are mediated by similar pathways and mechanisms in mouse and rat.
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A Behavioral Role for Dendritic Integration: HCN1 Channels Constrain Spatial Memory and Plasticity at Inputs to Distal Dendrites of CA1 Pyramidal Neurons
Matthew F. Nolan,Gaël Malleret,Josh T. Dudman,Derek L. Buhl,Bina Santoro,Emma Gibbs,Svetlana Vronskaya,György Buzsáki,Steven A. Siegelbaum,Eric R. Kandel,Alexei Morozov +10 more
TL;DR: It is suggested that HCN1 channels constrain learning and memory by regulating dendritic integration of distal synaptic inputs to pyramidal cells.