D
Diane M. Simeone
Researcher at University of Michigan
Publications - 297
Citations - 23025
Diane M. Simeone is an academic researcher from University of Michigan. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 66, co-authored 261 publications receiving 20569 citations. Previous affiliations of Diane M. Simeone include New York University & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Identification of Pancreatic Cancer Stem Cells
Chenwei Li,David G. Heidt,Piero Dalerba,Charles F. Burant,Lanjing Zhang,Volkan Adsay,Max S. Wicha,Michael F. Clarke,Diane M. Simeone +8 more
TL;DR: This work identified a highly tumorigenic subpopulation of pancreatic cancer cells expressing the cell surface markers CD44, CD24, and epithelial-specific antigen (ESA) that showed the stem cell properties of self-renewal, the ability to produce differentiated progeny, and increased expression of the developmental signaling molecule sonic hedgehog.
Journal ArticleDOI
Phenotypic characterization of human colorectal cancer stem cells
Piero Dalerba,Scott J. Dylla,In-Kyung Park,Rui Liu,Xinhao Wang,Robert W. Cho,Timothy Hoey,Austin L. Gurney,Emina Huang,Diane M. Simeone,Andrew A. Shelton,Giorgio Parmiani,Chiara Castelli,Michael F. Clarke +13 more
TL;DR: The results validate the stem cell working model in human CRC and provide a highly robust surface marker profile for CRC stem cell isolation.
Journal ArticleDOI
Identification of pancreatic cancer stem cells
TL;DR: This work identified a highly tumorigenic subpopulation of pancreatic cancer cells expressing the cell surface markers CD44, CD24, and epithelial-specific antigen (ESA) that showed the stem cell properties of self-renewal, the ability to produce differentiated progeny, and increased expression of the developmental signaling molecule sonic hedgehog.
Journal ArticleDOI
Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments
Ilona Kryczek,Mousumi Banerjee,Pui Cheng,Linhua Vatan,Wojciech Szeliga,Shuang Wei,Emina Huang,Emily Finlayson,Diane M. Simeone,Theodore H. Welling,Alfred E. Chang,George Coukos,Rebecca Liu,Weiping Zou +13 more
TL;DR: scientific and clinical rationale for developing novel immune-boosting strategies based on promoting the Th17 cell population in cancer patients are provided and inhibition of Th17 cells represents a novel immune evasion mechanism are provided.
Journal Article
Molecular Profiling of Pancreatic Adenocarcinoma and Chronic Pancreatitis Identifies Multiple Genes Differentially Regulated in Pancreatic Cancer
Craig D. Logsdon,Diane M. Simeone,Charles E. Binkley,Thiruvengadam Arumugam,Joel K. Greenson,Thomas J. Giordano,David E. Misek,Samir M. Hanash +7 more
TL;DR: In this article, microarray data were used to profile gene expression in pancreatic adenocarcinoma (10), pancreatic cancer cell lines (7), chronic pancreatitis (5), and normal pancreas (5).