Flavivirus NS1 Triggers Tissue-Specific Vascular Endothelial Dysfunction Reflecting Disease Tropism
Henry Puerta-Guardo,Dustin R. Glasner,Diego A. Espinosa,Scott B. Biering,Mark Patana,Kalani Ratnasiri,Chunling Wang,P. Robert Beatty,Eva Harris +8 more
TLDR
It is demonstrated that NS1 from dengue, Zika, West Nile, Japanese encephalitis, and yellow fever viruses selectively binds to and alters permeability of human endothelial cells from lung, dermis, umbilical vein, brain, and liver in vitro and causes tissue-specific vascular leakage in mice, reflecting the pathophysiology of each flavivirus.About:
This article is published in Cell Reports.The article was published on 2019-02-05 and is currently open access. It has received 168 citations till now. The article focuses on the topics: Flavivirus & Dengue virus.read more
Citations
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Journal ArticleDOI
Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies.
Suowen Xu,Iqra Ilyas,Peter J. Little,Hong Li,Danielle Kamato,Xueying Zheng,Sihui Luo,Zhuoming Li,Peiqing Liu,Jihong Han,Ian C. Harding,Eno E. Ebong,Scott J. Cameron,Alastair G. Stewart,Jianping Weng +14 more
TL;DR: In this article, the authors provide a timely overview of the multiple layers of endothelial function, describe the consequences and mechanisms of the endothelial dysfunction, and identify pathways to effective targeted therapies.
Journal ArticleDOI
Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells.
Nilda Vanesa Ayala-Nunez,Nilda Vanesa Ayala-Nunez,Gautier Follain,François Delalande,Aurélie Hirschler,Emma Partiot,Gillian Hale,Brigid C. Bollweg,Judith R.E. Roels,Maxime Chazal,Florian Bakoa,Margot Carocci,Sandrine Bourdoulous,Orestis Faklaris,Sherif R. Zaki,Anita Eckly,Béatrice Uring-Lambert,Frédéric Doussau,Sarah Cianférani,Christine Carapito,Frank M. J. Jacobs,Nolwenn Jouvenet,Jacky G. Goetz,Raphael Gaudin,Raphael Gaudin +24 more
TL;DR: It is shown in ex vivo and in vivo models that ZIKV can hitch a ride in monocytes in a Trojan Horse manner to cross the endothelium and disseminate the virus.
Journal ArticleDOI
Mechanisms of Pathogen Invasion into the Central Nervous System
TL;DR: Advances in understanding of the CNS invasion mechanisms of different neurotropic pathogens may enable the development of strategies to control their entry and deliver drugs to mitigate established infections.
Journal ArticleDOI
Structural basis for antibody inhibition of flavivirus NS1–triggered endothelial dysfunction
Scott B. Biering,David L. Akey,Marcus P Wong,W. Clay Brown,Nicholas T. N. Lo,Henry Puerta-Guardo,Francielle Tramontini Gomes de Sousa,Chunling Wang,Jamie R. Konwerski,Diego A. Espinosa,Nicholas J. Bockhaus,Dustin R. Glasner,Jeffrey S Li,Sophie F. Blanc,Evan Y. Juan,Stephen J. Elledge,Michael J. Mina,P. Robert Beatty,Janet L. Smith,Eva Harris +19 more
TL;DR: In this article, three crystal structures of full-length dengue virus NS1 complexed with a flavivirus-cross-reactive, NS1-specific monoclonal antibody, 2B7, at resolutions between 2.89 and 3.96 angstroms were presented.
Journal ArticleDOI
The Glycocalyx and Its Role in Vascular Physiology and Vascular Related Diseases
TL;DR: Many important developments in the basic understanding of GCX structure, function and role in diseases have been described since the 2007 paper, and the future is wide open for continued GCX research.
References
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Zika Virus Associated with Microcephaly
Jernej Mlakar,Miša Korva,Mateja Poljšak-Prijatelj,Jerica Mraz,Marko Kolenc,Katarina Resman Rus,Tina Vesnaver Vipotnik,Vesna Fabjan,Alenka Vizjak,Miroslav Petrovec +9 more
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TL;DR: A review of state-of-the-art knowledge on the composition and functions of the endothelial glycocalyx can be found in this article, where the contribution of the glyocalyx to diabetes, ischemia/reperfusion, and atherosclerosis is also reviewed.
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Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth
Hengli Tang,Christy Hammack,Sarah C. Ogden,Zhexing Wen,Xuyu Qian,Yujing Li,Bing Yao,Jaehoon Shin,Feiran Zhang,Emily M. Lee,Kimberly M. Christian,Ruth Didier,Peng Jin,Hongjun Song,Guo Li Ming +14 more
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Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
Tian Wang,Terrence Town,Lena Alexopoulou,Lena Alexopoulou,John F. Anderson,Erol Fikrig,Richard A. Flavell +6 more
TL;DR: Tlr3-deficient mice were more resistant to lethal WNV infection and had impaired cytokine production and enhanced viral load in the periphery, whereas in the brain, viral load, inflammatory responses and neuropathology were reduced compared to wild-type mice.
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