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Diego A. Pizzagalli
Researcher at Harvard University
Publications - 393
Citations - 27176
Diego A. Pizzagalli is an academic researcher from Harvard University. The author has contributed to research in topics: Anhedonia & Medicine. The author has an hindex of 74, co-authored 327 publications receiving 21846 citations. Previous affiliations of Diego A. Pizzagalli include Stanford University & McLean Hospital.
Papers
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Journal ArticleDOI
Mechanisms of Memory Disruption in Depression
TL;DR: It is argued that many memory deficits in depression appear to be downstream consequences of chronic stress, and addressing memory disruption can have therapeutic value.
Journal ArticleDOI
Individual differences in reinforcement learning: behavioral, electrophysiological, and neuroimaging correlates.
Diane L. Santesso,Daniel G. Dillon,Jeffrey L. Birk,Avram J. Holmes,Elena L. Goetz,Ryan Bogdan,Diego A. Pizzagalli +6 more
TL;DR: Findings raise the possibility that learners in the probabilistic reinforcement task were characterized by stronger dACC and BG responses to rewarding outcomes, and highlight the importance of the dACC to Probabilistic reward learning in humans.
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Functional connectomics of affective and psychotic pathology.
Justin T. Baker,Daniel G. Dillon,Lauren M. Patrick,Joshua L. Roffman,Roscoe O. Brady,Diego A. Pizzagalli,Diego A. Pizzagalli,Dost Öngür,Dost Öngür,Avram J. Holmes +9 more
TL;DR: Variation in functional connectomes across psychiatric diagnoses is examined, finding striking evidence for disease connectomic “fingerprints” that are commonly disrupted across distinct forms of pathology and appear to scale as a function of illness severity.
Journal ArticleDOI
Associative processing and paranormal belief
TL;DR: A novel task for the quantitative assessment of both originality and speed of individual associations and a model of association behavior that captures both ‘positive’ psychological aspects and ‘negative’ aspects is proposed, and its relevance for psychiatry is outlined.
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A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia
Andrew D. Krystal,Andrew D. Krystal,Diego A. Pizzagalli,Moria J. Smoski,Sanjay J. Mathew,Sanjay J. Mathew,John I. Nurnberger,Sarah H. Lisanby,Dan V. Iosifescu,James W. Murrough,Hongqiu Yang,Richard D. Weiner,Joseph R. Calabrese,Gerard Sanacora,Gretchen Hermes,Richard S.E. Keefe,Allen W. Song,Wayne K. Goodman,Steven T. Szabo,Steven T. Szabo,Alexis E. Whitton,Alexis E. Whitton,Keming Gao,William Z. Potter +23 more
TL;DR: A phase 2 proof-of-mechanism trial shows that a κ-opioid receptor antagonist improves reward-related functioning in the brain and a clinical measure of anhedonia in patients with mood and anxiety disorders, serving as a model for implementing the ‘fast-fail’ approach to psychiatric treatment development.