Diego A. Pizzagalli

TL;DR: Striatal hypersensitivity during stress might constitute a trait mark of depression, providing a potential neural substrate for the interaction between stress and reward dysfunction in MDD.

TL;DR: The caudate is identified as a region with dissociable incentive-dependent dACC connectivity abnormalities in major depressive disorder, and initial evidence that cortico-striatal circuitry may play a role in MDD treatment response is provided.

TL;DR: The LPP may be a sensitive probe of depressive rumination, whereas FRN-linked theta activity may represent a neural marker of hypersensitivity to negative outcomes in depressed youth.

TL;DR: Irrespective of past MDD episodes, women with a history of CSA showed neural and behavioral deficits in utilizing previous reinforcement to optimize decision making in the absence of feedback (blunted "Go learning").

TL;DR: FMRI captures the acute affective and neural responses to naturalistic positive mood induction, as well as their spontaneous fluctuations during resting states, and suggests that corticostriatal pathways contribute to the natural time course of positive mood fluctuations, while disturbances of those neural interactions may characterize mood disorder.