Diego A. Pizzagalli

TL;DR: The findings suggest that the insula and dACC are important substrates of smoking relapse vulnerability and suggest that relapse-vulnerable smokers can be identified before quit attempts, which could enable personalized treatment, improve tobacco-dependence treatment outcomes, and reduce smoking-related morbidity and mortality.

TL;DR: It is found that anhedonia, but not other symptoms of depression or anxiety, was correlated with reduced nucleus accumbens responses to rewards, and reward responses were inversely associated with rACC resting delta activity, supporting the hypothesis that delta might be lawfully related to activity within the brain's reward circuit.

TL;DR: Reward-related learning reflected at least two partially separable contributions related to phasic prediction error signalling, and was preferentially modulated by a low dose of the dopamine agonist pramipexole in MDD and anhedonia.

TL;DR: It is suggested that subgenual PFC dysfunction in melancholia may be associated with blunted hedonic response and exaggerated stress responsiveness, and a negative correlation between gray matter density and age emerged.

TL;DR: In this article, the authors proposed four methodological desiderata for studying how task-irrelevant affect modulates cognition and presented data from an experiment satisfying them, consistent with accounts of the hemispheric asymmetries characterizing withdrawal-related negative affect and visuospatial working memory.