D
Dan V. Iosifescu
Researcher at New York University
Publications - 244
Citations - 15709
Dan V. Iosifescu is an academic researcher from New York University. The author has contributed to research in topics: Major depressive disorder & Randomized controlled trial. The author has an hindex of 58, co-authored 211 publications receiving 12971 citations. Previous affiliations of Dan V. Iosifescu include Nathan Kline Institute for Psychiatric Research & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Reduced Caudate and Nucleus Accumbens Response to Rewards in Unmedicated Individuals With Major Depressive Disorder
Diego A. Pizzagalli,Avram J. Holmes,Daniel G. Dillon,B.A. Elena L. Goetz,B.A. Jeffrey L. Birk,A.M. Ryan Bogdan,Darin D. Dougherty,Dan V. Iosifescu,Scott L. Rauch,Maurizio Fava +9 more
TL;DR: Results suggest that basal ganglia dysfunction in major depression may affect the consummatory phase of reward processing, and morphometric results suggest that anhedonia in major Depression is related to caudate volume.
Journal ArticleDOI
A mega-analysis of genome-wide association studies for major depressive disorder
Stephan Ripke,Naomi R. Wray,Cathryn M. Lewis,Steven P. Hamilton,Myrna M. Weissman,Gerome Breen,Enda M. Byrne,Douglas Blackwood,Dorret I. Boomsma,Sven Cichon,Andrew C. Heath,Florian Holsboer,Susanne Lucae,Pamela A. F. Madden,Nicholas G. Martin,Peter McGuffin,Pierandrea Muglia,Markus M. Noethen,Brenda P Penninx,Michele L. Pergadia,James B. Potash,Marcella Rietschel,Danyu Lin,Bertram Müller-Myhsok,Jianxin Shi,Stacy Steinberg,Hans J. Grabe,Paul Lichtenstein,Patrik K. E. Magnusson,Roy H. Perlis,Martin Preisig,Jordan W. Smoller,Kari Stefansson,Rudolf Uher,Zoltán Kutalik,Katherine E. Tansey,Alexander Teumer,Alexander Viktorin,Michael R. Barnes,Thomas Bettecken,Elisabeth B. Binder,René Breuer,Victor M. Castro,Susanne Churchill,William Coryell,Nicholas John Craddock,Ian W. Craig,Darina Czamara,Eco J. C. de Geus,Franziska Degenhardt,Anne Farmer,Maurizio Fava,Josef Frank,Vivian S. Gainer,Patience J. Gallagher,Scott D. Gordon,Sergey Goryachev,Magdalena Gross,Michel Guipponi,Anjali K. Henders,Stefan Herms,Ian B. Hickie,Susanne Hoefels,Witte J.G. Hoogendijk,Jouke-Jan Hottenga,Dan V. Iosifescu,Marcus Ising,Ian Jones,Lisa Jones,Tzeng Jung-Ying,James A. Knowles,Isaac S. Kohane,Martin A. Kohli,Ania Korszun,Mikael Landén,William Lawson,Glyn Lewis,Donald J. MacIntyre,Wolfgang Maier,Manuel Mattheisen,Patrick J. McGrath,Andrew M. McIntosh,Alan W. McLean,Christel M. Middeldorp,Lefkos T. Middleton,G. M. Montgomery,Shawn N. Murphy,Matthias Nauck,Willem A. Nolen,Dale R. Nyholt,Michael Conlon O'Donovan,Hogni Oskarsson,Nancy L. Pedersen,William A. Scheftner,Andrea Schulz,Thomas G Schulze,Stanley I. Shyn,Engilbert Sigurdsson,Susan L. Slager,Johannes H. Smit,Hreinn Stefansson,Michael Steffens,Thorgeir E. Thorgeirsson,Federica Tozzi,Jens Treutlein,Manfred Uhr,Edwin J. C. G. van den Oord,Gerard van Grootheest,Henry Völzke,Jeffrey B. Weilburg,Gonneke Willemsen,Frans G. Zitman,Benjamin M. Neale,Mark J. Daly,Douglas F. Levinson,Patrick F. Sullivan +115 more
TL;DR: This article conducted a genome-wide association studies (GWAS) mega-analysis for major depressive disorder (MDD) using more than 1.2 million autosomal and X chromosome single-nucleotide polymorphisms (SNPs) in 18,759 independent and unrelated subjects of recent European ancestry.
Journal ArticleDOI
Antidepressant Efficacy of Ketamine in Treatment-Resistant Major Depression: A Two-Site Randomized Controlled Trial
James W. Murrough,Dan V. Iosifescu,Lee C. Chang,Rayan K. Al Jurdi,Charles Green,Andrew M. Perez,Syed Z Iqbal,Sarah Pillemer,Alexandra Foulkes,Asim A Shah,Dennis S. Charney,Sanjay J. Mathew +11 more
TL;DR: Ketamine demonstrated rapid antidepressant effects in an optimized study design, further supporting NMDA receptor modulation as a novel mechanism for accelerated improvement in severe and chronic forms of depression.
Journal ArticleDOI
Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task
TL;DR: These findings indicate that MDD is characterized by an impaired tendency to modulate behavior as a function of prior reinforcements, and provides initial clues about which aspects of hedonic processing might be dysfunctional in depression.
Journal ArticleDOI
Rapid and Longer-Term Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression
James W. Murrough,Andrew M. Perez,Sarah Pillemer,Jessica Stern,Michael K. Parides,Marije aan het Rot,Katherine A. Collins,Sanjay J. Mathew,Sanjay J. Mathew,Dennis S. Charney,Dan V. Iosifescu +10 more
TL;DR: Ketamine was associated with a rapid antidepressant effect in TRD that was predictive of a sustained effect and future controlled studies will be required to identify strategies to maintain an antidepressant response among patients who benefit from a course of ketamine.