D
Diego Jaitin
Researcher at Weizmann Institute of Science
Publications - 48
Citations - 10017
Diego Jaitin is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Chromatin & Immune system. The author has an hindex of 26, co-authored 45 publications receiving 7394 citations.
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Journal ArticleDOI
XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis.
Aleksandra Deczkowska,Aleksandra Deczkowska,Eyal David,Pierluigi Ramadori,Dominik Pfister,Michael Safran,Amir Giladi,Diego Jaitin,Oren Barboy,Merav Cohen,Merav Cohen,Ido Yofe,Chamutal Gur,Chamutal Gur,Shir Shlomi-Loubaton,Sandrine Henri,Yousuf Suhail,Mengjie Qiu,Shing Kam,Hila Hermon,Eylon Lahat,Gil Ben Yakov,Oranit Cohen-Ezra,Yana Davidov,Mariya Likhter,David Goitein,David Goitein,Susanne Roth,Achim Weber,Bernard Malissen,Assaf Weiner,Ziv Ben-Ari,Ziv Ben-Ari,Mathias Heikenwalder,Eran Elinav,Eran Elinav,Ido Amit +36 more
TL;DR: In this paper, using single-cell transcriptomic analysis, a significant pathology-associated increase in hepatic conventional dendritic cells (cDCs) and further defined their source as NASH-induced boost in cycling of cDC progenitors in the bone marrow.
Journal ArticleDOI
Variations in the unstructured C-terminal tail of interferons contribute to differential receptor binding and biological activity.
TL;DR: From the results, it is suggested that the unstructured tail of IFNalpha is gaining a specific structure in the bound state, binding to a groove below the 132-134 loop in IFNAR2.
Journal ArticleDOI
Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours
Tereza Golias,Ioanna Papandreou,Ramon C. Sun,Bhavna Kumar,Nicole V. Brown,Benjamin Swanson,Reetesh K. Pai,Diego Jaitin,Quynh-Thu Le,Theodoros N. Teknos,Nicholas C. Denko +10 more
TL;DR: PDHK1 activity is unique and non-redundant in the family of PHDK enzymes and a PDHK1 specific inhibitor would therefore have anti-cancer activity with reduced chance of side effects from inhibition of other PDHKs.
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Distinct biological events generated by ECM proteolysis by two homologous collagenases
Inna Solomonov,Eldar Zehorai,Dalit Talmi-Frank,Sharon G. Wolf,Alla Shainskaya,Alina Zhuravlev,Elena Kartvelishvily,Robert Visse,Yishai Levin,Nir Kampf,Diego Jaitin,Eyal David,Ido Amit,Hideaki Nagase,Irit Sagi +14 more
TL;DR: It is observed that proteolysis of collagen-rich natural extracellular matrix (ECM), performed uniquely by individual homologous proteases, leads to distinct events that eventually affect overall ECM morphology, viscoelastic properties, and molecular composition.
Journal ArticleDOI
Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules.
Asaf Zviran,Nofar Mor,Yoach Rais,Hila Gingold,Shani Peles,Elad Chomsky,Sergey Viukov,Jason D. Buenrostro,Jason D. Buenrostro,Roberta Scognamiglio,Leehee Weinberger,Yair S. Manor,Vladislav Krupalnik,Mirie Zerbib,Hadas Hezroni,Diego Jaitin,David Larastiaso,Shlomit Gilad,Sima Benjamin,Ohad Gafni,Awni Mousa,Muneef Ayyash,Daoud Sheban,Jonathan Bayerl,Alejandro Aguilera-Castrejon,Rada Massarwa,Itay Maza,Suhair Hanna,Yonatan Stelzer,Igor Ulitsky,William J. Greenleaf,Amos Tanay,Andreas Trumpp,Ido Amit,Yitzhak Pilpel,Noa Novershtern,Jacob H. Hanna +36 more
TL;DR: Functional validations highlight interweaved epigenetic- and Myc-governed essential reconfigurations that rapidly commission and propel deterministic reprogramming toward naive pluripotency.