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Diego Jose Laderach
Researcher at National University of Luján
Publications - 21
Citations - 698
Diego Jose Laderach is an academic researcher from National University of Luján. The author has contributed to research in topics: Galectin & Tumor microenvironment. The author has an hindex of 14, co-authored 21 publications receiving 591 citations. Previous affiliations of Diego Jose Laderach include National Scientific and Technical Research Council & French Institute of Health and Medical Research.
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Journal ArticleDOI
A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease
Diego Jose Laderach,Lucas Daniel Gentilini,Laura Giribaldi,Víctor M. Cárdenas Delgado,Lorena G. Nugnes,Diego O. Croci,Nader Al Nakouzi,Paula Alejandra Sacca,Gabriel Casas,Osvaldo Mazza,Margaret A. Shipp,Elba Vazquez,Anne Chauchereau,Jeffery L. Kutok,Scott J. Rodig,María T. Elola,Daniel Compagno,Gabriel A. Rabinovich +17 more
TL;DR: A dynamically regulated "galectin-specific signature" that accompanies disease evolution in prostate cancer is identified and highlighted, highlighting a major role for Gal-1 as a tractable target for antiangiogenic therapy in advanced stages of the disease.
Journal ArticleDOI
RNA Interference Shows Critical Requirement for NF-κB p50 in the Production of IL-12 by Human Dendritic Cells
Diego Jose Laderach,Daniel Compagno,Olivier Danos,T. William Vainchenker,Anne Galy,Anne Galy +5 more
TL;DR: RNA interference was used to assess the role of the p50 (NF-κB1) protein in the maturation and activation of cultured human monocyte-derived DC, revealing a pivotal requirement for p50 in MoDC for IL-12 production and induction of optimal type-1 immune responses.
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Galectin-1 triggers epithelial-mesenchymal transition in human hepatocellular carcinoma cells.
María L. Bacigalupo,Malena Manzi,María V. Espelt,Lucas Daniel Gentilini,Daniel Compagno,Diego Jose Laderach,Carlota Wolfenstein-Todel,Gabriel A. Rabinovich,María F. Troncoso +8 more
TL;DR: Extensive Gal1 expression facilitated the transition from epithelial cell morphology towards a fibroblastoid phenotype and favored up‐regulation of the mesenchymal marker vimentin in HCC cells, with critical implications in H CC metastasis.
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Galectin-8: a matricellular lectin with key roles in angiogenesis.
María F. Troncoso,Fátima Ferragut,María L. Bacigalupo,Víctor M. Cárdenas Delgado,Lorena G. Nugnes,Lucas Daniel Gentilini,Diego Jose Laderach,Carlota Wolfenstein-Todel,Daniel Compagno,Gabriel A. Rabinovich,María T. Elola +10 more
TL;DR: A novel role for gal-8 is described in the regulation of vascular and lymphatic angiogenesis and evidence of its critical implications in tumor biology is provided, including cell adhesion and migration, which collectively demonstrate the multi-functionality of this complex lectin.
Journal ArticleDOI
Dissecting the signal transduction pathways triggered by galectin–glycan interactions in physiological and pathological settings
Diego Jose Laderach,Daniel Compagno,Marta A. Toscano,Diego O. Croci,Sebastián Dergan-Dylon,Mariana Salatino,Gabriel A. Rabinovich,Gabriel A. Rabinovich +7 more
TL;DR: Current knowledge on the intracellular signaling pathways triggered by this multifunctional family of β‐galactoside‐binding proteins in selected physiological and pathological settings are discussed.