Dilansu Guneykaya

TL;DR: It is shown that male microglia are more frequent in specific brain areas, have a higher antigen-presenting capacity, and appear to have aHigher potential to respond to stimuli such as ATP, reflected in higher baseline outward and inward currents and higher protein expression of purinergic receptors.

TL;DR: Using the MIA mouse model, minocycline treatment of adult MIA offspring reverted completely the transcriptional, functional and behavioral deficits, highlighting the potential benefits of therapeutic targeting of microglia in psychiatric disorders.

TL;DR: It is found that a subset of let-7 miRNAs function as signaling molecules to induce microglial release of inflammatory cytokines, modulate antigen presentation, and attenuate cell migration in a TLR7-dependent manner.

TL;DR: The physiological properties of plaque-associated microglia are altered with a strong impact on purinergic signaling, and this change was accompanied by changes in membrane properties and potassium channel activity ofaques in early and late stages of amyloidosis.

TL;DR: It is concluded that in parallel to an alleviation of the symptoms in the rat MIA model, deep brain stimulation has the potential to prevent the neuroinflammatory component in this disease.