C
Carmelo Ferrai
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 23
Citations - 1900
Carmelo Ferrai is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Transcription (biology) & Enhancer. The author has an hindex of 17, co-authored 20 publications receiving 1620 citations. Previous affiliations of Carmelo Ferrai include Vita-Salute San Raffaele University & Imperial College London.
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Journal ArticleDOI
Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells
Erik Arner,Carsten O. Daub,Kristoffer Vitting-Seerup,Robin Andersson,Berit Lilje,Finn Drabløs,Andreas Lennartsson,Michelle Rönnerblad,Olga Hrydziuszko,Morana Vitezic,Tom C. Freeman,Ahmad M. N. Alhendi,Peter Arner,Richard A Axton,J Kenneth Baillie,Anthony G Beckhouse,Beatrice Bodega,James Briggs,Frank Brombacher,Margaret B. Davis,Michael Detmar,Anna Ehrlund,Mitsuhiro Endoh,Afsaneh Eslami,Michela Fagiolini,Lynsey Fairbairn,Geoffrey J. Faulkner,Carmelo Ferrai,Malcolm E. Fisher,Lesley M. Forrester,Dan Goldowitz,Reto Guler,Thomas J. Ha,Mitsuko Hara,Meenhard Herlyn,Tomokatsu Ikawa,Chieko Kai,Hiroshi Kawamoto,Levon M. Khachigian,S. Peter Klinken,Soichi Kojima,Haruhiko Koseki,Sarah Klein,Niklas Mejhert,Ken Miyaguchi,Yosuke Mizuno,Mitsuru Morimoto,Kelly J. Morris,Christine L. Mummery,Yutaka Nakachi,Soichi Ogishima,Mariko Okada-Hatakeyama,Yasushi Okazaki,Valerio Orlando,Dmitry A. Ovchinnikov,Robert Passier,Margaret Patrikakis,Ana Pombo,Xian-Yang Qin,Sugata Roy,Hiroki Sato,Suzana Savvi,Alka Saxena,Anita Schwegmann,Daisuke Sugiyama,Rolf Swoboda,Hiroshi Tanaka,Andru Tomoiu,Louise N. Winteringham,Ernst J. Wolvetang,Chiyo Yanagi-Mizuochi,Misako Yoneda,Susan E. Zabierowski,Peter G. Zhang,Imad Abugessaisa,Nicolas Bertin,Alexander D. Diehl,Shiro Fukuda,Masaaki Furuno,Jayson Harshbarger,Akira Hasegawa,Fumi Hori,Sachi Ishikawa-Kato,Yuri Ishizu,Masayoshi Itoh,Tsugumi Kawashima,Miki Kojima,Naoto Kondo,Marina Lizio,Terrence F. Meehan,Christopher J. Mungall,Mitsuyoshi Murata,Hiromi Nishiyori-Sueki,Serkan Sahin,Sayaka Nagao-Sato,Jessica Severin,Michiel J. L. de Hoon,Jun Kawai,Takeya Kasukawa,Timo Lassmann,Harukazu Suzuki,Hideya Kawaji,Kim M. Summers,Christine A. Wells,David A. Hume,Alistair R. R. Forrest,Albin Sandelin,Piero Carninci,Yoshihide Hayashizaki +108 more
TL;DR: The data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during cellular differentiation or activation.
Journal ArticleDOI
Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation
James Fraser,Carmelo Ferrai,Carmelo Ferrai,Andrea M. Chiariello,Markus Schueler,Tiago Rito,Giovanni Laudanno,Mariano Barbieri,Benjamin L. Moore,Dorothee C. A. Kraemer,Stuart Aitken,Sheila Q. Xie,Kelly J. Morris,Kelly J. Morris,Masayoshi Itoh,Hideya Kawaji,Ines Jaeger,Yoshihide Hayashizaki,Piero Carninci,Alistair R. R. Forrest,Colin A. Semple,Josée Dostie,Ana Pombo,Mario Nicodemi,Mario Nicodemi +24 more
TL;DR: Using polymer modelling, it is demonstrated that hierarchical folding promotes efficient chromatin packaging without the loss of contact specificity, highlighting a role far beyond the simple need for packing efficiency.
Journal ArticleDOI
FANTOM5 CAGE profiles of human and mouse samples
Shuhei Noguchi,Takahiro Arakawa,Shiro Fukuda,Masaaki Furuno,Akira Hasegawa,Fumi Hori,Sachi Ishikawa-Kato,Kaoru Kaida,Ai Kaiho,Mutsumi Kanamori-Katayama,Tsugumi Kawashima,Miki Kojima,Atsutaka Kubosaki,Ri Ichiroh Manabe,Mitsuyoshi Murata,Sayaka Nagao-Sato,Kenichi Nakazato,Noriko Ninomiya,Hiromi Nishiyori-Sueki,Shohei Noma,Eri Saijyo,Akiko Saka,Mizuho Sakai,Christophe Simon,Naoko Suzuki,Michihira Tagami,Shoko Watanabe,Shigehiro Yoshida,Peter Arner,Richard A Axton,Magda Babina,J Kenneth Baillie,Timothy C. Barnett,Anthony G Beckhouse,Antje Blumenthal,Beatrice Bodega,Alessandro Bonetti,James Briggs,Frank Brombacher,Frank Brombacher,Ailsa J Carlisle,Hans Clevers,Hans Clevers,Carrie A. Davis,Michael Detmar,Taeko Dohi,B. Albert S. Edge,Matthias Edinger,Anna Ehrlund,Karl Ekwall,Mitsuhiro Endoh,Hideki Enomoto,Afsaneh Eslami,Michela Fagiolini,Lynsey Fairbairn,Mary C. Farach-Carson,Geoffrey J. Faulkner,Carmelo Ferrai,Malcolm E. Fisher,Lesley M. Forrester,Rie Fujita,Jun Ichi Furusawa,Teunis B. H. Geijtenbeek,Thomas R. Gingeras,Dan Goldowitz,Sven Guhl,Reto Guler,Reto Guler,Stefano Gustincich,Stefano Gustincich,Thomas J. Ha,Masahide Hamaguchi,Mitsuko Hara,Yuki Hasegawa,Meenhard Herlyn,Peter Heutink,Kelly J Hitchens,David A. Hume,Tomokatsu Ikawa,Yuri Ishizu,Chieko Kai,Hiroshi Kawamoto,Yuki I. Kawamura,Judith S. Kempfle,Tony J. Kenna,Juha Kere,Juha Kere,Levon M. Khachigian,Toshio Kitamura,Sarah Klein,S. Peter Klinken,Alan J. Knox,Soichi Kojima,Haruhiko Koseki,Shigeo Koyasu,Weon Ju Lee,Andreas Lennartsson,Alan Mackay-Sim,Niklas Mejhert,Yosuke Mizuno,Hiromasa Morikawa,Mitsuru Morimoto,Kazuyo Moro,Kelly J. Morris,Hozumi Motohashi,Christine L. Mummery,Yutaka Nakachi,Yutaka Nakachi,Fumio Nakahara,Toshiyuki Nakamura,Yukio Nakamura,Tadasuke Nozaki,Soichi Ogishima,Naganari Ohkura,Hiroshi Ohno,Mitsuhiro Ohshima,Mariko Okada-Hatakeyama,Yasushi Okazaki,Valerio Orlando,Dmitry A. Ovchinnikov,Robert Passier,Margaret Patrikakis,Ana Pombo,Swati Pradhan-Bhatt,Xian-Yang Qin,Michael Rehli,Patrizia Rizzu,Sugata Roy,Antti Sajantila,Shimon Sakaguchi,Hiroki Sato,Hironori Satoh,Suzana Savvi,Suzana Savvi,Alka Saxena,Christian Schmidl,Claudio Schneider,Gundula Schulze-Tanzil,Anita Schwegmann,Anita Schwegmann,Guojun Sheng,Jay W. Shin,Daisuke Sugiyama,Takaaki Sugiyama,Kim M. Summers,Naoko Takahashi,Jun Takai,Hiroshi Tanaka,Hideki Tatsukawa,Andru Tomoiu,Hiroo Toyoda,Marcvande Wetering,Linda M. van den Berg,Roberto Verardo,Dipti Vijayan,Christine A. Wells,Louise N. Winteringham,Ernst J. Wolvetang,Yoko Yamaguchi,Masayuki Yamamoto,Chiyo Yanagi-Mizuochi,Misako Yoneda,Yohei Yonekura,Peter G. Zhang,Silvia Zucchelli,Imad Abugessaisa,Erik Arner,Jayson Harshbarger,Atsushi Kondo,Timo Lassmann,Marina Lizio,Serkan Sahin,Thierry Sengstag,Jessica Severin,Hisashi Shimoji,Masanori Suzuki,Harukazu Suzuki,Jun Kawai,Naoto Kondo,Masayoshi Itoh,Carsten O. Daub,Takeya Kasukawa,Hideya Kawaji,Piero Carninci,Alistair R. R. Forrest,Yoshihide Hayashizaki +185 more
TL;DR: In the FANTOM5 project, transcription initiation events across the human and mouse genomes were mapped at a single base-pair resolution and their frequencies were monitored by CAGE coupled with single-molecule sequencing to represent the consequence of transcriptional regulation in each analyzed state of mammalian cells.
Journal ArticleDOI
Arx Is a Direct Target of Dlx2 and Thereby Contributes to the Tangential Migration of GABAergic Interneurons
Gaia Colasante,Patrick Collombat,Valentina Raimondi,Dario Bonanomi,Carmelo Ferrai,Mario Maira,Kazuaki Yoshikawa,Ahmed Mansouri,Flavia Valtorta,John L.R. Rubenstein,Vania Broccoli +10 more
TL;DR: Although Arx has additional functions independent of the Dlx pathway, it is established a direct genetic relationship that controls critical steps in the development of telencephalic GABAergic neurons, contributing to elucidating the genetic hierarchy that likely underlies the etiology of a variety of human neurodevelopmental disorders.
Journal ArticleDOI
Maternal immune activation results in complex microglial transcriptome signature in the adult offspring that is reversed by minocycline treatment.
Daniele Mattei,Andranik Ivanov,Carmelo Ferrai,Philipp Jordan,Dilansu Guneykaya,Alice Buonfiglioli,Wandert Schaafsma,Piotr Przanowski,Winnie Deuther-Conrad,Peter Brust,Swen Hesse,Marianne Patt,Osama Sabri,T L Ross,Bart J. L. Eggen,Erik Boddeke,Bozena Kaminska,Dieter Beule,Ana Pombo,Helmut Kettenmann,Susanne A. Wolf +20 more
TL;DR: Using the MIA mouse model, minocycline treatment of adult MIA offspring reverted completely the transcriptional, functional and behavioral deficits, highlighting the potential benefits of therapeutic targeting of microglia in psychiatric disorders.