Dipak K. Das

TL;DR: It is demonstrated that GSPE is highly bioavailable and provides significantly greater protection against free radicals and free radical-induced lipid peroxidation and DNA damage than vitamins C, E and beta-carotene.

TL;DR: The published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources, and animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials.

TL;DR: It is demonstrated that IH636 grape seed proanthocyanidin extract (GSPE) provides superior antioxidant efficacy as compared to Vitamins C, E and beta-carotene and may serve as a potential therapeutic tool in promoting cardiovascular health via a number of novel mechanisms.

TL;DR: Evidence is provided that resveratrol exhibits potent anti-inflammatory activity and the mechanisms discussed address foremost mechanisms for the anti- inflammatory activity which, in turn, is responsible for cardioprotection.

TL;DR: The results of this study demonstrate that resveratrol possesses cardioprotective effects which may be attributed to its peroxyl radical scavenging activity and suggest a probable mechanism involved in the protective ability of RVT.