Journal ArticleDOI
Anti-inflammatory responses of resveratrol.
Samarjit Das,Dipak K. Das +1 more
TLDR
Evidence is provided that resveratrol exhibits potent anti-inflammatory activity and the mechanisms discussed address foremost mechanisms for the anti- inflammatory activity which, in turn, is responsible for cardioprotection.Abstract:
Resveratrol (trans-3,4',5-trihydroxystilbene), a natural polyphenolic, non-flavonoid antioxidant, is a phytoalexin found in many plants including grapes, nuts and berries. Recent studies have documented that resveratrol has various health benefits, such as cardiovascular and cancer preventive properties. However, the experimental basis for such health benefit is not fully understood. One of the possible mechanisms for its protective activities is by down regulation of the inflammatory responses. That includes the inhibition of synthesis and release of pro-inflammatory mediators, modifications of eicosanoid synthesis, inhibition of some activated immune cells, or inhibiting the enzymes, such as cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2), which are responsible for the synthesis of pro-inflammatory mediators through the inhibitory effect of resveratrol on transcription factors like nuclear factor kappaB (NFkappaB) or activator protein-1 (AP-1). Being a phenolic compound, resveratrol certainly possesses a low bioavailability and most importantly, a rapid clearance from the plasma. Recent growing interest in varying protective nature of resveratrol may clinically also hold a respectable position as a better alternative for anti-inflammatory drugs. The purpose of this review is to provide evidence that resveratrol exhibits potent anti-inflammatory activity and also to explain the underling mechanism for both resveratrol- induced cardioprotective and anti-inflammatory properties. While it is true that the cardioprotective properties of resveratrol are likely attributable, at least in part, to its anti-inflammatory properties, the mechanisms discussed address foremost mechanisms for the anti-inflammatory activity which, in turn, is responsible for cardioprotection.read more
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Journal ArticleDOI
AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan.
TL;DR: The AMPK pathways involved in the inhibition of NF-κB signaling and suppression of inflammation are reviewed and it is emphasized that the capacity of AMPK to repress inflammatory responses can have a significant impact on both healthspan and lifespan.
Journal ArticleDOI
The Molecular Targets of Resveratrol
Sameer S. Kulkarni,Carles Cantó +1 more
TL;DR: The most recent advances in the field are covered, with special focus on the metabolic actions of resveratrol and the potential role of SIRT1 and AMPK.
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Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets
TL;DR: The role of HSCs in liver fibrosis is outlined and novel strategies to suppress HSC activity are details, thereby providing new insights into potential treatments for liver Fibrosis.
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Resveratrol: its biologic targets and functional activity.
Shazib Pervaiz,Andrea L. Holme +1 more
TL;DR: A comprehensive account of the basic chemistry of RSV, its bioavailability, and its multiple intracellular target proteins and signaling pathways is presented.
Journal ArticleDOI
Resveratrol as an anti-cancer agent: A review
Abdur Rauf,Muhammad Imran,Masood Sadiq Butt,Muhammad Nadeem,Dennis G. Peters,Mohammad S. Mubarak +5 more
TL;DR: Grapes are a prominent and promising source of phytochemicals, especially resveratrol, a phytoalexin antioxidant found in red grapes which has both chemopreventive and therapeutic effects against various ailments.
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