D
Ditlev E. Brodersen
Researcher at Aarhus University
Publications - 88
Citations - 9982
Ditlev E. Brodersen is an academic researcher from Aarhus University. The author has contributed to research in topics: RNA & Antitoxin. The author has an hindex of 33, co-authored 82 publications receiving 9277 citations. Previous affiliations of Ditlev E. Brodersen include La Trobe University & Laboratory of Molecular Biology.
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Journal ArticleDOI
Structure of the 30S ribosomal subunit.
Brian T. Wimberly,Ditlev E. Brodersen,William M. Clemons,William M. Clemons,Robert J. Morgan-Warren,Andrew P. Carter,Clemens Vonrhein,Thomas Hartsch,Venki Ramakrishnan +8 more
TL;DR: The crystal structure of the 30S subunit from Thermus thermophilus, refined to 3 Å resolution, is reported, which will facilitate the interpretation in molecular terms of lower resolution structural data on several functional states of the ribosome from electron microscopy and crystallography.
Journal ArticleDOI
Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics
Andrew P. Carter,William M. Clemons,William M. Clemons,Ditlev E. Brodersen,Robert J. Morgan-Warren,Brian T. Wimberly,Venki Ramakrishnan +6 more
TL;DR: The functional implications of the high-resolution 30S crystal structure are described, and details of the interactions between the 30S subunit and its tRNA and mRNA ligands are inferred, which lead to a model for the role of the universally conserved 16S RNA residues A1492 and A1493 in the decoding process.
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Recognition of Cognate Transfer RNA by the 30S Ribosomal Subunit
James M. Ogle,Ditlev E. Brodersen,William M. Clemons,Michael J. Tarry,Andrew P. Carter,Venki Ramakrishnan +5 more
TL;DR: Crystal structures of the 30S ribosomal subunit in complex with messenger RNA and cognate transfer RNA in the A site, both in the presence and absence of the antibiotic paromomycin, have been solved at between 3.1 and 3.3 angstroms resolution.
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The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit
Ditlev E. Brodersen,William M. Clemons,William M. Clemons,Andrew P. Carter,Robert J. Morgan-Warren,Brian T. Wimberly,Venki Ramakrishnan +6 more
TL;DR: The recently determined atomic structure of the 30S ribosomal subunit is used to determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and hygromycin B to suggest a mechanism for its effects on ribosome function.
Journal ArticleDOI
Toxins, Targets, and Triggers: An Overview of Toxin-Antitoxin Biology
TL;DR: How multiple levels of regulation shape the conditions of toxin activation to achieve the different biological functions of TA modules is highlighted.